特异性免疫治疗变应性鼻炎的临床疗效观察及对患者预后生活品质的影响.docVIP

精品论文 参考文献 特异性免疫治疗变应性鼻炎的临床疗效观察及对患者预后生活品质的影响 杨世权 阎萍 通讯作者 龚为群 蒋勇峰 任霞斌 周晶 　　（上海市徐汇区大华医院耳鼻咽喉科上海200237） 　　 　　基金项目：上海市徐汇区医学课题（ZKKT201110）【摘要】目的：探讨特异性免疫治疗变应性鼻炎的临床疗效及对患者预后生活品质的影响。方法：以我院近年来收治的变应性鼻炎患者180例作为研究对象，根据患者意愿及随机方式分为观察组和对照组各90例；对照组采用常规药物进行治疗，观察组患者采取特异性免疫治疗；对患者治疗效果进行分析。结果：治疗后第14周，两组疗效无显著差异，P＞005；治疗后第18月和第36月，观察组治疗有效率为778%和867%，明显优于对照组478%和267%，均P＜005。观察组3年复发率为89%（8/90），明显低于对照组911%（82/90），并具有显著差异(P＜005)。治疗后第36月观察组VAS各项得分明显低于对照组，均P＜005。结论：采取特异性免疫治疗变应性鼻炎相对于常规治疗疗效更佳，能够改善患者远期疗效并减少复发率，使患者预后生活品质得以提升。 　　【关键词】特异性免疫治疗；变应性鼻炎；发病率；生活品质Specific immune treatment the clinical effect of the treatment of allergic rhinitis 　　Yang Shiquan Yanping Gong Weiqun Ren Xiabin Zhangdan Wang WeilingDahua Hospital of Shanghai Xuhui District,Shanghai 200237Medical topics if Shanghai Xuhui District （ZKKT201110）Author for correspondence:YanpingMedical topics if Shanghai Xuhui District （ZKKT201110）Author for correspondence:Yanping 　　【Abstract】Objective:To study the specific immunotherapy for allergic rhinitis the clinical curative effect and influence on prognosis of patients quality of life.Methods:180 cases of allergic rhinitis patients admitted in our hospital in recent years as the research object,according to the patients with willingness and randomly divided into observation group and the control group (n = 90;In the control group using conventional drug treatment,observation group of patients taking specific immune therapy;For the patient treatment effect are analyzed.Results:14 weeks after the treatment,two groups of curative effect,no significant differences (Pgt;005);The first 18 months and the first 36 months after treatment,observation of the treatment group effective rate was 778% and 778%,significantly better than the control group were 478% and 267%,Plt;005).Observation group 3 year recurrence rate was 89% (8/90),significantly lower than the control group 911% (82/90),and have significant difference (Plt;005).The first 36 months observation group after treatment VAS