噪声导致的肝细胞间的周期钙波研究.pdf

王宝华等 No.: 0925 噪声导致的肝细胞间的周期钙波◆ ★ 王宝华 陆启韶 1北京航空航天大学理学院，北京 100083 摘要 本文以1999 年HÖfer 构建的肝细胞内钙振动的模型为基础，主要研究了由若干耦合的肝细胞组成的随机系统受高 斯白噪声影响产生的周期钙波的时空共振性质。通过数值模拟得到当噪声微弱时，随机系统内不出现任何形式的细胞间 钙波，在中等噪声强度时系统中出现有序的周期环形钙波，系统内波的环数随着噪声的增强而增加，而过大的噪声又会 摧毁系统内钙波的空间有序性，因此得到在中等噪声区间存在最优的噪声强度使得随机系统时空共振性达到最好。同样， 当噪声强度相同时，较小的耦合强度只能随机激发系统的某些细胞发生钙离子浓度振动但其不能扩散促使细胞间钙波形 成，而较大的耦合强度又使得钙离子浓度沿梯度方向扩散过快也不能形成空间斑图，通过对共振度量的计算得到存在最 优的耦合强度使得随机系统时空共振性达到最优。另外，从计算结果中我们观察到系统中钙波的宽度随耦合强度的增加 而增加并给出了拟合关系式。 关键词 细胞间钙波，耦合，白噪声 Intercellular Periodical Calcium Waves Induced by Noise in a Coupled Hepatocytes System Wang Bao-hua Lu Qi-shao School of Science, Beijing University of Aeronautics-Astronautics, Beijing 100083, China Abstract Spatiotemporal characters for calcium induced by weak Gaussian white noise in coupled hepatocytes are studied numerically in this paper. Because very weak noise cannot arose the system any response and great noise induces the system much random, it is obtained numerically that there must be an optimal noise intensity making the resonance of the system arriving maximum. Furthermore, changing coupling strength in the stochastic system for fixed noise intensity, when all the hepatocytes are independently, there is only some calcium eruptions stochastically which can not come into being any whole waves. While greater coupling coefficient induces the calcium oscillation diffusing too quickly, it is also gained the result that is similar to the above. Finally, the depe