经皮椎体成形术联合放疗治疗脊椎骨转移瘤的临床分析.docVIP

精品论文 参考文献 经皮椎体成形术联合放疗治疗脊椎骨转移瘤的临床分析 岳阳广济医院骨一科 湖南岳阳 414000 【摘 要】目的：探讨消瘤止痛膏联合唑来膦酸治疗恶性肿瘤骨转移引起疼痛的疗效。方法：选取74例脊椎骨转移瘤患者进行对照研究，其中对照组和观察组各37例；对照组采取放疗治疗，观察组采取经皮椎体成形术联合放疗治疗；对比两组患者治疗前后的VAS评分、ODI评分，根据EORTC 评分，综合评价患者的生活质量改善情况。结果：治疗后，观察组VAS评分、ODI评分显著低于治疗前水平（P＜0.05），且与对照组对比，具有显著性差异（P＜0.05）；治疗前，两组患者的EORTC 评分无显著性差异（P＞0.05）；治疗后，观察组患者的EORTC 评分显著低于对照组（P＜0.05）。结论：经皮椎体成形术联合放疗治疗脊椎骨转移瘤的临床效果确切，重建脊柱的稳定性，可协同缓解疼痛、提高日常活动功能、改善生活质量，具有临床可行性。 【关键词】脊椎骨转移瘤；经皮椎体成形术；放疗 [Abstract]Objective：To investigate the analgesic cream joint Xiaoliu zoledronic acid treatment of cancer pain caused by bone metastases efficacy.Methods：74 cases of spinal metastases were compared，in which the control group and the observation group 37 cases；the control group received radiotherapy treatment，observation group received percutaneous vertebroplasty combined with radiotherapy；comparing two groups of patients before and after treatment VAS score，ODI score，according to EORTC score，quality of life，comprehensive evaluation of the patients improvement.Results：After treatment，the observation group VAS score，ODI scores were significantly lower than the level before treatment（Plt;0.05），and the control group compared with a significant difference（Plt;0.05）；before treatment，both groups of patients EORTC score None significant difference（Pgt;0.05）；after treatment，the observation group were significantly lower than the scores of the EORTC control group（Plt;0.05）.Conclusion：Percutaneous vertebroplasty combined with radiotherapy for spinal metastases clinical exact effect，rebuild spinal stability，synergistically to relieve pain，improve daily activity function，improve quality of life，clinical feasibility. Keywords：spine metastases；Percutaneous vertebroplasty；radiotherapy 骨骼系统作为晚期恶性肿瘤转移的常见部位，以脊椎骨转移瘤最为常见，往往丧失治愈的可能性，对椎体和附件具有不同程度的侵袭[1]。在临床上，脊椎骨转移瘤以疼痛、神经功能障碍为主要症状，生活质量较差，治疗目的以缓解症状、提高日常活动功能，改善生活质量为主。放疗治疗脊椎骨转移瘤的效果确切，可直接杀灭肿瘤细胞，起到局部治疗作用，可缓解疼痛，但起效较慢，且不能改善因椎体破坏导致的脊柱不稳。经皮椎体成形术作为重建脊柱稳定性、止痛的微创治疗方法，可协同提高放疗治疗脊椎骨转移瘤的效果。对此，本研究旨在探讨消瘤止痛膏联合唑来膦酸治疗恶性