菌群与肠道疾病.ppt

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2018-01-16 发布于江苏
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菌群与肠道疾病.ppt

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菌群与肠道疾病

* * * * * 肠 * * * I * L. casei乳酸杆菌 * Double blind placebo controlled trial at 14 day care centers in israel with 201 patients Infants received formula or formula with probiotic 培菲康三联活菌治疗前后肠道菌群变化菌名治疗前治疗4周后乳酸杆菌 7.55±1.16 8.85±0.54* 双岐杆菌 9.04±0.99 10.51±0.45** 拟杆菌 10.89±0.84 10.12±0.74* 产气荚膜梭菌 9.34±0.91 8.97±0.97 肠球菌 9.43±0.97 7.20±1.15** 肠杆菌科 9.33±0.81 9.30±0.77 注：与正常对照组比较，* p 0.05；** p 0.01 ProbioticsMany Potential Uses Infectious diarrhea and day care related illness Antibiotic Associated Diarrhea Clostridium difficile Inflammatory bowel disease Traveler’s diarrhea Prevention of NEC Allergy Irritable Bowel Syndrome Yogurt (364) Yogurt+ L. casei (360) P-value Children with diarrhea 87 (22%) 61 (16%) 0.029 Duration of diarrhea (days) 3.95 3.53 0.24 Rotavirus positive stool 2.2% 0.3% Prevention of Diarrheal Illness 18 Week Therapy in French Children (6-24 months) in Day Care CA Pedone, et al. Int J Clin Pract 54(9):568-71, 2000 Controls (60) B. lactis (73) L. reuteri (68) P-value Days with diarrhea 0.59 0.37 0.15 0.001 Episodes of diarrhea 0.31 0.13 0.02 0.001 Clinic visits 0.55 0.51 0.23 0.002 Absences 0.43 0.41 0.14 0.015 Prevention of Diarrheal Illness 12 Week Therapy in Israeli Infants in Day Care Z Weizman, et al. Pediatrics 115:5-9, 2005 Controls (58) Lactobacillus GG (61) P-value Children with diarrhea 9 (16%) 3 (5%) 0.05 Duration of diarrhea (days) 4 4 NS Stool frequency (per day) 5 5 NS Prevention of Diarrheal Illness(After Antibiotics for Respiratory Illness) 2 Week Therapy in Finnish Children (2 weeks to 12 years) T Arvola, et al. Pediatrics 104(5), 1999 ProbioticsAntibiotic Associated Diarrhea S. boulardii Reduced rate of diarrhea in 116 patients versus placebo Lactobacillus GG Decreased diarrhea in people treated with triple therapy for H. pylori Found to reduce days of diarrhea and side effects when