肝硬化患者血清白蛋白、前白蛋白、总胆汁酸和脂蛋白联合检测分析.docVIP

精品论文 参考文献 肝硬化患者血清白蛋白、前白蛋白、总胆汁酸和脂蛋白联合检测分析 周阳春1 唐彦2 （1四川省自贡市第一人民医院检验科 643000;2重庆市中医骨科医院检验科 400010） 【中图分类号】R575.2【文献标识码】A【文章编号】1672-5085（2012）16-0055-02 【摘要】目的 探讨不同Child Pugh级别肝硬化患者血清白蛋白、前白蛋白、总胆汁酸和脂蛋白的变化及临床意义。方法 将269例肝硬化患者按Child Pugh分级标准分为三级，同时选择89例健康人作为对照组，空腹采集血清标本，在日立7600-010型全自动生化分析仪上测定样品Alb、PA、TBA、HDL-C和LDL-C浓度。结果 肝硬化患者各功能级别的TBA水平显著高于对照组(Plt;0.05)，且C级高于B级，B级高于A级(Plt;0.05)；而Alb、PA、HDL-C 、LDL-C水平显著低于对照组(Plt;0.05)，且C级低于B级，B级低于A级(Plt;0.05)。结论 肝硬化患者血清TBA水平与病情严重程度呈正相关，而Alb、PA、HDL-C和LDL-C均与病情严重程度呈负相关。联合检测各项指标，有利于肝硬化的诊断、治疗监测及预后判断。 【关键词】肝硬化 白蛋白 前白蛋白 总胆汁酸 脂蛋白 Analysis of combined detection of albumin, prealbumin, total bile acid and lipoprotein in liver cirrhosis patients 【Abstract】 Objective To discuss the clinical significance on the change of albumin, prealbumin, total bile acid and lipoprotein in liver cirrhosis patients. Method 269 cases of liver cirrhosis patients were divided by Child Pugh into three group. 89 cases of healthiers were selected for control group(Plt;0.05). Fasting serum samples were taken for determination of Alb,PA,TBA,HDL-C,LDL-C using Hitachi 7600-010 type automatic biochemistry analyzer. Results Serum TBA concentration in liver cirrhosis patients was higher than the control group(Plt;0.05). it was higher in grade A group than that in grade B group. And it was higher in grade B group than that in grade C group. The concentration of Alb, PA, HDL-C, LDL-C was significantly lower than the control group(Plt;0.05). The concentration of the above indexes in grade C was significantly lower than that in grade B. And they were also significantly lower in grade B than that in grade A(Plt;0.05). Conclusion And a significant positive correlation were observed between TBA concentration and disease severity. There was a significant negative correlation between the concentration of Alb, PA, HDL-C, LDL-C and disease severity. 【Key words】liver cirrhosis albumin prealbumin total bile acid lipoprotein 肝硬化（liver cirrhosis,LC）是一种常见的慢性肝病，可由一种或多种原因引起肝脏