肝硬化患者血清中胃蛋白酶原及胃泌素-17的表达及意义.docVIP

精品论文 参考文献 肝硬化患者血清中胃蛋白酶原及胃泌素-17的表达及意义 成都中医药大学附属医院感染科 四川成都610075 　　通讯作者：扈晓宇 主任医师 成都中医药大学附属医院感染科 　　【摘要】目的：探讨肝硬化患者血清中胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）及胃泌素-17（G-17）的表达水平及临床意义。方法：选取2014年1月-2016年1月在我院治疗的肝硬化患者114例作为研究组，并选择同期114例健康人作为对照组，采用酶联免疫吸附（ELISA）法检测2组患者空腹血清PGⅠ、PGⅡ、G-17水平。结果：肝硬化患者的PGⅠ、PGⅡ、G-17水平均明显高于健康对照组（Plt;0.05）； 肝硬化患者PGⅠ、PGⅡ、G-17水平随着Child-Pugh分级呈递增趋势，Child-Pugh C级患者PGⅠ、PGⅡ、G-17水平均明显高于Child-Pugh A级、Child-Pugh B级患者指标通水平（Plt;0.05）；Child-Pugh B级患者PGⅠ、G-17水平明显高于Child-Pugh A级指标水平（Pgt;0.05）；但两组患者的血清PGⅡ水平无明显差异（Pgt;0.05），伴PHG肝硬化患者的PGⅠ、G-17水平明显高于无PHG患者指标水平（Pgt;0.05）；但两组患者的血清PGⅡ水平无明显差异（Pgt;0.05）。结论：肝硬化可能影响血清PGⅠ、PGⅡ、G-17水平，且与肝功能分级与门脉高压性胃病相关，可作为评估及治疗肝硬化的参考指标。 　　【关键词】肝硬化；胃蛋白酶原Ⅰ；胃蛋白酶原Ⅱ；胃泌素-17 　　In Serum Of Patients With Liver Cirrhosis Pepsin and The Gastric Secrete Element-17 Expression And Meaning 　　【Abstract 】Objective: To study the patients with cirrhosis serum pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PG Ⅱ) and gastric secrete element --17 (G -17) expression level and clinical significance.Methods: January 2014 - January 2016 in our hospital treated 114 cases of patients with liver cirrhosis as a team, and select the same period 114 cases of healthy people as control group, using enzyme-linked immunosorbent (ELISA) method to detect two groups patients fasting serum PG Ⅰ, PG Ⅱ, G - 17 levels. Results: the patients with cirrhosis of PG Ⅰ, PG Ⅱ, G - 17 levels were significantly higher than that of healthy controls (Plt;0.05); PG Ⅰ in patients with cirrhosis, PG Ⅱ, G - 17 level with Child - Pugh, grading showed A trend of increasing, the Child - Pugh C level in patients with PG Ⅰ, PG Ⅱ, G - 17 levels were significantly higher than that of the Child - Pugh, A level, the Child - Pugh, index level B patients (P lt; 0.05); Child - Pugh, PG Ⅰ, G - B patients 17 level obviously higher than that of the Child - Pugh, A level indicator level (P gt; 0.05); But the level of the serum PG Ⅱ two groups of patients with no significant difference (P gt; 0.05), with PHG patients with cirrhosis of PG Ⅰ, G - 17 le