脑胶质瘤复发时间影响因素分析.docVIP

精品论文 参考文献 脑胶质瘤复发时间影响因素分析 亓欣 张磊* (第二军医大学附属长征医院神经外二科lt;上海市神经外科研究所gt; 200003) 【中图分类号】R739.41【文献标识码】A【文章编号】1672-5085（2012）19-0063-03 【摘要】目的 探讨影响胶质瘤复发时间的相关因素。方法 收集2000.04～2009.04在上海长征医院经手术治疗，有完整随访资料且术后胶质瘤复发的患者资料，对相关因素与胶质瘤复发时间的关系进行统计分析。结果 单因素分析结果显示患者年龄、术前KPS评分、术前癫痫、病理类型及术后放/化疗与脑胶质瘤复发时间相关（Plt;0.05），再次行多因素COX比例风险模型回归分析提示患者年龄、病理类型及术后放/化疗有统计学意义（Plt;0.05）。结论 患者胶质瘤术后复发时间与预后密切相关，应正确判断患者的一般情况，根据术中情况及肿瘤性质在术后选择合适的放、化疗，采用手术治疗辅以术后放、化疗的综合疗法，从而达到满意的治疗效果。 【关键词】胶质瘤 复发 预后 Analysis of factors on the time of glioma as recurrance Qixin Zhang Lei* Department of Neurosuegery，Changzheng Hospital，Second Military Medical University，Shanghai Institute of Neurosurgery，Shanghai 200003，China 【Abstract】Objective To analyze the correlated factors on the time of glioma as recurrence. Methods:Data of patients with glioma who were taken operation from April, 2000 to April, 2009 in ChangZheng Hospital and were recurred after operation was collectd.Then stastiscal analysis of the correlated factors on the time of glioma as recurrence was taken.Result:Univariate analysis demonstrated that patientsrsquo; age, KPS score, epilepsy before surgery, pathologic grade, and radiotherapy/ chemotherapy were the significant factors on the time of glioma as recurrence.The result of multivariate COX analysis showed that age, pathologic grade and radiotherapy/ chemotherapy were significantly correlated with the time of glioma as recurrence. Conclusion: The time of glioma as recurrence was significantly correlated with patientsrsquo; prognosis, so we should evaluate patientsrsquo; general state of health correctly, make suitable therapy according to the information from the operation and the character of tumor to get satisfactory therapeutic efficancy. 【Key words】glioma recurrence prognosis 胶质瘤是颅内最常见恶性肿瘤之一，发病率占全部原发性颅内肿瘤的40%～50%[1]，目前治疗上首选手术切除为主，辅以放、化疗的综合治疗措施，但胶质瘤多呈浸润性生长，术中很难完全切除病灶，术后复发率较高。而第一次手 术治疗时间与肿瘤复发间隔的时间越短预示肿瘤生长越快，患者预后也就越差[2]，因此，延缓胶质瘤复发是目前临床工作的关键。本文通过分析相关病例资料，初步探讨了其临床病理因素对胶质瘤复发时间的影响。