自体CIK+DC细胞免疫治疗肺癌74例的护理.docVIP

精品论文 参考文献 自体CIK+DC细胞免疫治疗肺癌74例的护理 朱晓娟 　　自贡市第一人民医院肿瘤科 四川自贡 643000 　　【摘 要】目的：总结自体CIK+DC细胞免疫疗法治疗肺癌患者的护理经验。探讨CIK+DC细胞免疫治疗中的注意事项。方法：对我科74例肺癌患者进行CIK+DC细胞免疫治疗，均在层流室进行，严格执行无菌操作，观察患者的不良反应，对CIK+DC细胞免疫治疗进行规范化护理。结果：3例患者出现低热，1例患者出现高热，经对症支持治疗后均降至正常，其余患者均顺利完成全程治疗，未出现任何不良反应。生活质量有不同程度的提高。结论：CIK+DC细胞免疫治疗能有效的提高患者的生活质量和治疗效果，且实施方便，不良反应少，是肿瘤患者增强机体免疫力功能和提高生活质量的新免疫治疗方法。 　　【关键词】CIK；DC；细胞免疫；治疗；肺癌；护理 　　【中图分类号】R473 【文献标识码】B 【文章编号】1674-8999（2015）8-0319-02 　　Autologous CIK + DC cell immune treatment of 74 cases of lung cancer care 　　Zhu Xiao juan 　　(Zigong city first peoples hospitaloncology,Si Chuan,Zi Gong643000) 　　【abstract】 objective: to summarize the autologous CIK + DC cellular immune therapy nursing experience for the treatment of patients with lung cancer. Discuss the matters of attention in the CIK + DC cells immunotherapy. Methods: my families and 74 cases of patients with lung cancer immunotherapy CIK + DC cells, are conducted in the laminar flow room, strict aseptic operation, observe the patients adverse reactions, CIK + DC cells immunotherapy for standard care. Results: 3 cases of patients with low thermal, 1 case of patients with high fever, after treatment for symptomatic support all down to normal, the rest of the patients were successfully completed the entire treatment, without any adverse reaction. The quality of life have different degrees of increase. Conclusion: CIK + DC cellular immune therapy can effectively improve the patients quality of life and treatment effect, and the implementation of convenient, less adverse reaction, is to enhance immunity function in patients with tumor and improve the quality of life of the new immune therapy. 　　【key words】CIK. DC; Cellular immunity; Treatment; Lung cancer; nursing 　　CIK细胞疗法是抽取患者自身的外周血（即细胞因子诱导的杀伤细胞主要将人体外周血单个核细胞在体外多种因子等同培养一段时间后获得的一群对肿瘤细胞有杀伤效应的异志细胞）在体外共同培养时经过复制和汇居过程，使它们的数量和活性得到大幅度的提高，然后将它们回输给患者，增强其机体抗肿瘤的能力，从而达到杀灭肿瘤细胞的目的。［1］ DC细胞疗法通过采用病人自体的单个核细胞在体外培养诱导生成DC，然后负载相应的肿瘤抗原，制成负载肿瘤抗原的DC，再将这些DC细胞注入体内后刺激体内的肿瘤杀伤性淋巴细胞增殖，发挥长期肿瘤监视作用