内源性含硫气体分子的心血管调节（英文）-课件，幻灯，PPTPPT.ppt

Endogenous Sulfur-containing Gaseous Molecules Cardiovascular Regulation;;E;Modulates cardiac contractility;Some work we did on the role of H2S in pathogenesis of CVDs:;H2S donor decreased BP and lessened the vascular structural remodeling in the rat aorta ;Relax blood vessels;The ratio of the plasma H2S/Hcy decreased in children with hypertension;H2S and Cardiovascular Diseases;In rats with hypoxic pulmonary hypertension, endogenous H2S/CSE pathway down-regulated obviously;H2S donor decreased hypoxic pulmonary hypertension and attenuated RV hypertrophy;H2S donor relieved the hypoxic pulmonary vascular structural remodeling;H2S inhibited hypoxic proliferation of pulmonary artery smooth muscle cell and induced hypoxic apoptosis of PASMCs;H2S reduced the collagen I and III abnormal accumulation in the pulmonary artery of the hypoxic rats;Endogenous H2S is positively correlated with lung function;inferior vena cava;marker D1 D3 W1 W4 W8 W11 ; sham shunt+PAG shunt; H2S donor reversed pulmonary hypertension and lessened pulmonary vascular structural remodeling; Mechanism by which H2S attenuated pulmonary hypertension; Plasma H2S level decreased markedly Negative correlation between plasma H2S level and pulmonary artery pressure was created (R= -0.864) ;H2S and Cardiovascular Diseases;H2S Vascular calcification;H2S Vascular calcification;H2S and Cardiovascular Diseases;H2S HHcy;Hcy-induced mitochondrial respiration inhibition ;H2S and Cardiovascular Diseases;H2S shock;H2S and Cardiovascular Diseases;Endogenous H2S production was reduced in ISO-induced myocardial injury ;H2S protects the structure and the contractility of the myocardium The mechanism is associated with the getting rid of free radicals;Endogenous H2S production was inhibited in cardiomyopathy induced by adriamycin (ADR);NaHS-treatment improved ADR-induced depression of cardiac functions;NaHS-treatment lessened ADR-