响应面试验优化复凝聚法制备槲皮素微胶囊工艺及其理化性质-食品科学.PDFVIP

20 2016, Vol.37, No.22 食品科学 ※工艺技术 响应面试验优化复凝聚法制备槲皮素微胶囊 工艺及其理化性质 1 1 1 1 1,2,* 廖 霞 ，杨小兰，李 瑶 ，王丽颖，明 建 （1.西南大学食品科学学院，重庆 400715 ；2.重庆市特色食品工程技术研究中心，重庆 400715 ） 摘  要：以槲皮素为芯材，壳聚糖、海藻酸钠为壁材，采用复凝聚法制备槲皮素微胶囊。以包埋率和载药量为综 合评价指标，通过单因素试验和响应面试验分析各因素，并对槲皮素微胶囊的理化性质进行研究。结果表明：壁 - 1 3.34 g/g 4.34 1 g/g 18.44 g/100 g壳聚糖、固化温度 材比（壳聚糖 海藻酸钠质量比） ∶ （ ）、芯壁比 ∶ （ ）、京尼平用量 41.56 69.53% 3.26% 40.39 256.44 μg/mL ℃时，包埋率为 。制备的槲皮素微胶囊水分含量为 ，休止角为 °，溶解度为 ，粒 径大小较为均匀，平均粒径为1 362 nm ，具有较好的溶解性和稳定性。 关键词：槲皮素；复凝聚法；微胶囊；理化性质 Response Surface Optimization of Preparation of Microencapsulated Quercetin Using Complex Coacervation and Its Physicochemical Properties 1 1 1 1 1,2,* LIAO Xia , YANG Xiaolan , LI Yao , WANG Liying , MING Jian (1. College of Food Science, Southwest University, Chongqing 400715, China; 2. Chongqing Special Food Programme and Technology Research Center, Chongqing 400715, China) Abstract: Quercetin microcapsules were prepared by complex coacervation using sodium alginate and chitosan as the wall materials and quercetin as the core material. Single factor experiments and response surface methodology were employed to optimize the preparation conditions based on embedding rate and drug loading. The physicochemical properties of quercetin microcapsules were investigated as well. Under the optimized conditions: sodium alginate/chitosan ratio, 3.34:1; core/wall mat