通络定痫汤联合苯巴比妥治疗癫痫持续状态的临床疗效及其脑保护作用.docVIP

精品论文 参考文献 通络定痫汤联合苯巴比妥治疗癫痫持续状态的临床疗效及其脑保护作用 1青州市人民医院 山东 青州2625002寿光市人民医院 山东 寿光 262700 摘要：目的：分析通落定痫汤联合苯巴比妥治疗癫痫持续状态的临床疗效及其脑保护作用。方法：回顾性分析2015年1月～2016年1月期间在我院治疗的76例癫痫持续状态患者临床资料，依据就诊时间将其分为对照组和治疗组，每组38例患者，对照组患者采用苯巴比妥治疗，治疗组患者在对照组治疗的基础上，同期加用通落定痫汤治疗，治疗2个疗程（1个疗程15d）后，对比两组患者临床治疗疗效。结论：2个疗程后治疗组临床总有效率为97.36%，对照组临床总有效率为73.68%，差异有统计学意义（Plt;0.05）；治疗组患者意识恢复时间、癫痫控制时间均明显短于对照组，差异有统计学意义（Plt;0.05）；治疗组患者72h内意识恢复率明显高于对照组，差异有统计学意义（Plt;0.05）；治疗后2组患者NO、Ca+水平明显降低，与治疗前对比差异有统计学意义（Plt;0.05），治疗组、NO、Ca+水平低于对照组，差异有统计学意义（Plt;0.05）；治疗后2组患者神经细胞凋亡数明显减少，与治疗前对比差异有统计学意义（Plt;0.05），治疗组神经细胞凋亡数减少明显优于对照组，差异有统计学意义（Plt;0.05）；治疗后2组患者超氧化物歧化酶(SOD)、丙二醛(MDA)明显改善，与治疗前对比差有统计学意义（P＜0.05），治疗组与对照组对比，差异有统计学意义（P＜0.05）；在治疗和观察过程中，两组患者均未见严重副作用，差异无统计学意义(P＞0.05)。结论：通落定痫汤联合苯巴比妥治疗癫痫持续状态的临床疗效疗效确切，可以有效控制癫痫，促进患者意识恢复，并且对脑具有良好的保护作用，值得在临床推广和应用。 关键词：通落定痫汤；苯巴比妥；癫痫持续状态；脑保护作用 【中图分类号】R446【文献标识码】A【文章编号】1001-5213(2016)09-0109-02 Abstract: Objective: to analyse the epileptic decoction combined with phenobarbital treatment of status epilepticus clinical curative effect and the neuroprotective effect of settled. Methods: a retrospective analysis in January 2015 ~ January 2016 period in our hospital treatment of 76 cases of epilepsy lasts condition in patients with clinical data. According to the visiting time the into control group and treatment group, 38 patients in each group, control group were treated with phenobarbital treatment, patients in the treatment group according to treatment group, compared with epileptic Decoction in the treatment of settled. After treatment of 2 courses (a course of 15 days), compared two groups of patients with clinical curative effect. Conclusion: after 2 courses of treatment group clinical total effective rate was 97.36%, control group total effective rate was 73.68%, the difference was statistically significant (Plt;0.05); the patients in the treatment group consciousness recovery time, seizure control time were significantly shorter than the control group, the difference was statistically significant (Plt;0.05)