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趋化因子及其受体在神经系统发育中的作用-生命科学.pdf

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趋化因子及其受体在神经系统发育中的作用-生命科学

19 5 Vol. 19, No. 5 2007 10 Chinese Bulletin of Life Sciences Oct., 2007 1004-0374(2007)05-0536-07 ( 100050) R339.35, Q426 A Effects of chemokines and their receptors on the development of nervous system WANG Zhenzhen, HU Jinfeng, LI Gang, CHEN Naihong * (Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China) Abstract: Chemokines, a variety of chemotactic cytokines, play a pivotal part in the control of leukocyte trafficking. Because chemokines and their receptors were intimately involved in the orchestration of inflamma- tory responses and inducibly expressed, the initial researches were confined to the immune system. However, recent intriguing findings revealed the constructive expression of chemokines under some physiological con- ditions such as nerve cellular maturation and development. This review article summarizes the recent advances in the role of chemokines and their receptors in the development of nervous system and the mechanisms concerned, which will administer to penetrating understand the relationship of chemokines and the develop- ment of nervous system and will provide evidence for further research. Key words: chemokine/ chemokines; chemokine/ chemokines receptor; development of nervous system (chemotactic cytokines chemokines) (Mr=8 000 12 000 HIV 70 90 ) [1- 2] [3] 2007-06-06 2007-06-2