基于1HNMR代谢组学技术的D半乳糖致衰老大鼠尿液代谢谱的动态变化.pdfVIP

-514· ·ORIGINALARTlCLE· 一 linnururimfrOmtrOmD 。metabolicoliC ne profile…changchanges -galactose inducedrats 1H-NMRmetabonomics agingbased-i analysis ZHAo Fan-fanl，2，ZHOUYu—zhil，CHANGYan．fen3，GAOL-1，QINXue．meil，DUGuan—hual，4，ZHANGXian905 f1．ModemResearchCenterforTraditionalChineseMedicinel of andChemica| 2．CollegeChemistry chiⅪCare and Engineering,ShanxiUniversity,Taiyuan030006,China；3，MaternityHospital, of ShanxiProvincialChildren MateriaMedica。 Hospital,Taiyuan030006,china：4．Institute Chinese of Union 1 Medical Medical 00050。 Academy SciencesPekingCollege．Beijing of of Louisville。Louisville china：5．DepartmentChemistry|nUniversity 40228,UsA) the in metabolicinrats Abstract：OBJECTIVET0 urine investigatedynamicchanges profiles and induced to thecorrelationsbetweenthedifferentiaImetabolites byD-galactose(D—Gal)，andstudy behavior nuclear indicatorsthe resonance using proton magnetic f1H—NMR)-based METHODSSubcutaneousofD．GaI100 10weekswas inthemodeI injection ma·kg—for adopted ofurinewas