原创力文档N arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium activated potassium channels英文文献.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
British Journal of Pharmacology (2010), 160, 594–603
© 2010 The Authors
Journal compilation © 2010 The British Pharmacological Society All rights reserved 0007-1188/10
THEMED ISSUE: CANNABINOIDS
RESEARCH PAPER
N-arachidonoyl glycine, an endogenous lipid that
acts as a vasorelaxant via nitric oxide and large
bph_622 594..603
conductance calcium-activated potassium channels
Neelam Parmar and W-S Vanessa Ho
Division of Basic Medical Sciences, St George’s University of London, Cranmer Terrace, London, UK
Background and purpose: N-arachidonoyl glycine (NAGly) is an endogenous lipid that is structurally similar to the endocan-
nabinoid, N-arachidonoyl ethanolamide (anandamide). While NAGly does not activate cannabinoid receptors, it exerts
cannabimimetic effects in pain regulation. Here, we have determined if NAGly, like anandamide, modulates vascular tone.
Experimental approach: In rat isolated small mesenteric arteries, the relaxant responses to NAGly were characterized. Effects
of N-arachidonoyl serine and N-arachidonoyl g-aminobutyric acid were also examined.
Key results: In endothelium-intact arteries, NAGly-induced relaxation (pEC50% = 5.7 0.2; relaxation at 30 mM = 98 1%)
was attenuated by L-NAME (a nitric oxide synthase inhibitor) or iberiotoxin [selective blocker of large conductance Ca2+-
activated K+ channels (BKCa)], and abolished by high extracellular K+ concentration. Endothelial removal reduced the potency
of NAGly, a
您可能关注的文档
- WIND TUNNEL MODELLING OF CONVECTION OF HEAT BETWEEN AIR AND BROAD LEAVES OF PLANTS英文文献.pdf
- Sequence Analysis of Chromatin Immunoprecipitation Data for Transcription Factors英文文献.pdf
- A scheme for multisource interior tomography英文文献.pdf
- Argonaute proteins key players in RNA silencing英文文献.pdf
- Web Search Results Clustering Based on a Novel Suffix Tree Structure英文文献.pdf
- Robust Estimation of Ultrasound Pulses Using Outlier Resistant De Noising英文文献.pdf
- Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus英文文献.pdf
- Determination of Binding Stoichiometry by the Continuous Variation Method The Job Plot英文文献.pdf
- Robust and optimum designs of non linearly tapered slow light couplers英文文献.pdf
- Laser induced thermal response and characterization of nanoparticles for cancer treatment using magnetic resonance thermal imaging英文文献.pdf
- microRNA miR 144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease英文文献.pdf
- An Automated DICOM Database Capable of Arbitrary Data Mining Including Radiation Dose Indicators for Quality Monitoring英文文献.pdf
- VECTORIZED STRONGLY IMPLICIT SOLVING PROCEDURE FOR A SEVEN DIAGONAL COEFFICIENT MATRIX英文文献.pdf
- Surface Enhanced Raman Spectroscopy英文文献.pdf
- Fabrication and microstructure analysis on zinc oxide nanotubes英文文献.pdf
- Potentialities of substrate thinning technique to control minority carrier injection in smart power IC's英文文献.pdf
- ATM Activation by Oxidative Stress英文文献.pdf
- Analytical Solution of the Flow Field Induced by the Uniformly Moving Double Helical Vortex Filaments英文文献.pdf
- Bernstein type operator and their derivatives英文文献.pdf
- Experimental human challenge infections can accelerate clinical malaria vaccine development英文文献.pdf
文档评论（0）