氧化酶及烷烃氧化OxygenasesandOxygenationofAlkanes.PDF

2007 年第 27 卷 有 机 化 学 Vol. 27, 2007 第 2 期, 209～217 Chinese Journal of Organic Chemistry No. 2, 209～217 ·综述与进展· 氧化酶及烷烃氧化 姜 标 a 伍登熙 b 左亚军 b 郜 莉 b 李祖义*,a (a 中国科学院上海有机化学研究所 上海 200032) (b 上海华谊集团公司 上海 200025) 摘要 记述了氧化酶在生物催化中的应用. 较之传统的化学反应, 氧化还原生物催化反应有较好的选择性、可控性和 经济性, 人们正在积极地寻找这类催化剂. 自然界中被高度还原的烃类品种丰富, 因此催化烷烃末端或近末端氧合反 应的酶也相对容易找到. 很多这一类的酶生化特性已作了详细的描述, 烷烃加氧酶催化高附加值反应的潜力已得到了 广泛地认可. 关键词 氧化酶; 烷烃; 羟化酶 Oxygenases and Oxygenation of Alkanes JIANG, Biaoa WU, Deng-Xib ZUO, Ya-Junb GAO, Lib LI, Zu-Yi*,a (a Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032) (b Shanghai Huayi Company, Shanghai 200025) Abstract This article describes oxidising enzymes used for biocatalytic applications. Redox biocatalysts are highly sought after because of the selectivity, controllability and economy of their reactions, in compari- son with conventional chemical reactions. As highly reduced hydrocarbons are abundant in the environment, enzymes that catalyze the terminal or subterminal oxygenation of alkanes are relatively easy to find. A number of these enzymes have been biochemically characterized in detail, because the potential of alkane hydroxylases to catalyze high added-value reactions was widely recognized. Keywords oxygenase; alkane; hydroxylase 在精细化工、日用化学品乃至大化工产品中, 工业 大化工的活化中间体是很有潜力的, 因为通过化学方法 生物技术越来越显示出强大的作用. 到 2050 年, 生物催 使烃官能团化是十分困难、耗能且对环境有害的. 化和转化可能占到化工产