金花葵黄酮对高脂血症大鼠血脂的影响-食品科学.PDF

248 2012, Vol. 33, No. 01 食品科学 ※营养卫生 1 2 1, 李 芸 ，杨秀松 ，何计国 * (1. 中国农业大学食品科学与营养工程学院，北京 100083 ；2. 国家食品药品监督管理局培训中心，北京 100073) 目的：探讨金花葵黄酮对高脂血症模型大鼠血脂的影响。方法：100 只 SD 大鼠，按体质量随机分为 6 组；除空白对照组外，其余各组饲喂高脂饲料制作动物高脂血症模型；其中金花葵黄酮分为 3、30 、90mg/(kg ·d)剂 量组；阳性对照组灌胃洛伐他汀片 10mg/(kg ·d) ；空白对照组、阴性对照组灌胃 10mL/(kg ·d)蒸馏水，连续 6 周。每 两周测定血脂相关指标，最后一周测定氧化型低密度脂蛋白(ox-LDL) 。结果：3 个剂量组大鼠血清血脂水平(总胆 固醇(TC) 、甘油三酯(TG) 、低密度脂蛋白胆固醇(LDL-C))及 ox-LDL 明显降低。结论：金花葵黄酮能缓解大鼠高 脂血症，降低 ox-LDL 水平，延缓泡沫细胞的形成和动脉粥样硬化的发生。 金花葵；黄酮；高脂血症 Effect of Abelmoschus manihot Flavonoids on Blood Lipid Levels of Hyperlipidemic Rats 1 2 1, LI Yun ，YANG Xiu-song ，HE Ji-guo * (1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China； 2. Training Center of State Food and Drug Administration, Beijing 100073, China) Abstract：Objective: To explore the effect of Abelmoschus manihot flavonoids on blood lipids of hyperlipidemic rats. Methods: Totally 100 SD rats were divided randomly into 6 groups: normal control group, high-fat control group, lovastatin positive control group at the dose of 10 mg/(kg ·d), and flavonoid groups at low, middle and high doses (3, 30 mg/(kg ·d) and 90 mg/(kg ·d)). Except normal the control group, all groups were fed high-fat diet to establish a hyperlipidemia model. Normal control group and high-fat control group were given distilled water at the dose of 10 mL/(kg ·d) once a day for 6 consecutive weeks. Serum TC, TG, HDL-C, LDL-C, and ox-LDL were determined after the last administration. R