[工学]药物设计学课件 第八章 作用于离子通道的药物.pdfVIP

第八章作用于离子通道的药物 第一节离子通道简介 第二节作用于不同离子通道的药物 第一节离子通道简介 1.1 离子通道研究简史 1950-1960 Hodgkin 和Huxley，通道概念的提出 1965-1975 Hille和Armstrong ，离子选择性和门控机制 1981 Neher 与Sakmann，膜片钳制(patch clamp)技术 1998 Mackinnon，第一个离子通道结构 The Nobel Prize in Physiology or Medicine 1963 for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane Sir John Carew Eccles Alan Lloyd Hodgkin Andrew Fielding Huxley Australian National University University of Cambridge, London University Canberra, Australia Cambridge, United Kingdom London, United Kingdom The Nobel Prize in Physiology or Medicine 1991 for their discoveries concerning the function of single ion channels in cells Erwin Neher Bert Sakmann Max-Planck-Institut fur Max-Planck-Institut fur Biophysikalische Chemie medizinische Forschung Goettingen, Federal Republic of Heidelberg, Federal Germany Republic of Germany The Nobel Prize in Chemistry 2003 for discoveries concerning channels in cell membranes for the discovery of water for structural and mechanistic channels studies of ion channels Peter Agre Roderick MacKinnon Johns Hopkins Rockefeller University, Howard University School of Hughes Medical Institute Medicine New York, NY, USA Baltimore, MD, USA 1.2 离子通道 跨膜的生物大分子 作用类似于活化酶 具有离子泵的作用，产生和传导电信号 参与调节人体多种生理功能 离子通道示意图 神经递质 1.2.2 离子通道的类型： １ 电压门通道； ２ 配体门通道； ３ 机械门通道；