discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents：（发现基于介质环thiophosphorus杂环化合物作为抗增殖剂）.pdfVIP

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discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents：（发现基于介质环thiophosphorus杂环化合物作为抗增殖剂）.pdf

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discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents：（发现基于介质环thiophosphorus杂环化合物作为抗增殖剂）

Bioorganic Medicinal Chemistry Letters 27 (2017) 967–972 Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry Letters journal homepage: www.else /locate/bmcl Discovery of medium ring thiophosphorus based heterocycles as antiproliferative agents Wei Feng a,b, Wisna Novera c, Kaye Peh a, Donavan Neo a, Pondy Murugappan Ramanujulu a,b, Philip K. Moore b,d, Lih-Wen Deng c, Brian W. Dymock a,⇑ a Department of Pharmacy, Block S4A Level 3, 18 Science Drive 4, National University of Singapore, 117543, Singapore b Life Sciences Institute, Centre for Life Sciences Level 5, 28 Medical Drive, National University of Singapore, 117456, Singapore c Department of Biochemistry, Block MD7 #04-06, 8 Medical Drive, National University of Singapore, 117596, Singapore d Department of Pharmacology, UHL Level 5-02R, Lee Kong Chian Wing, 21 Lower Kent Ridge Road, National University of Singapore, 119077, Singapore a r t i c l e i n f o a b s t r a c t Article history: Hydrogen sulﬁde (H S) has been investigated for its potential in therapy. Recently, we reported novel H S 2 2 Received 19 August 2016 donor molecules based on a thiophosphorus core, which slowly release H2S and have improved anti-pro- Revised 21 December 2016 liferative activity in cancer cell lines compared to the most widely studied H2S donor GYY4137 (1). Accepted 29 December 2016 Herein, we have prepared new thiophosphorus organic H2S donors with different ring