原创力文档drug development for refractory epilepsy the past 25 years and beyond：（过去25年为难治性癫痫药物开发）.pdfVIP
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drug development for refractory epilepsy the past 25 years and beyond：（过去25年为难治性癫痫药物开发）
Seizure 44 (2017) 147–156
Contents lists available at ScienceDirect
Seizure
journal homepage: /locate/yseiz
Review
Drug development for refractory epilepsy: The past 25 years and
beyond
a a,b,*
Ambica Golyala , Patrick Kwan
a Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia
b Department of Neurology, Royal Melbourne Hospital, Parkville, Australia
A R T I C L E I N F O A B S T R A C T
Article history:
Received 31 October 2016 Despite the exponential growth of approved antiepileptic drugs (AEDs) over the past 25 years, epilepsy
Accepted 30 November 2016 remains uncontrolled in approximately a third of patients. This article summarises the clinical trials
and properties of the AEDs developed over this period, and reviews the pre-clinical and clinical
Keywords: development paradigms of modern AEDs. We discuss possible reasons for the apparent failure to
Antiepileptic drugs develop more efficacious compounds. We also review the current regulatory frameworks for drug
Epilepsy approval in the United States and Europe, and the changes on the horizon. Encouragingly, better
Clinical trials elucidation of the pathophysiological mechanisms underpinning pharmacoresistance and the
Animal models
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