drug discovery for hearing loss phenotypic screening of chemical compounds on primary cultures of the spiral ganglion：（药物发现为听力损失表型筛选化合物的主要文化螺旋神经节）.pdfVIP

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drug discovery for hearing loss phenotypic screening of chemical compounds on primary cultures of the spiral ganglion：（药物发现为听力损失表型筛选化合物的主要文化螺旋神经节）.pdf

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drug discovery for hearing loss phenotypic screening of chemical compounds on primary cultures of the spiral ganglion：（药物发现为听力损失表型筛选化合物的主要文化螺旋神经节）

Hearing Research 349 (2017) 177e181 Contents lists available at ScienceDirect Hearing Research journal homepage: /locate/heares Short review Drug discovery for hearing loss: Phenotypic screening of chemical compounds on primary cultures of the spiral ganglion Donna S. Whitlon a, b, c, * a Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA b Interdepartmental Neurosciences Program, Northwestern University, Chicago, IL, USA c Knowles Hearing Center, Northwestern University, Evanston, IL, USA a r t i c l e i n f o a b s t r a c t Article history: In the United States there are, at present, no drugs that are speciﬁcally FDA approved to treat hearing Received 17 June 2016 loss. Although several clinical trials are ongoing, including one testing D-methionine that is supported by Received in revised form the US Army, none of these trials directly address the effect of noise exposure on cochlear spiral ganglion 21 July 2016 neurons. We recently published the ﬁrst report of a systematic chemical compound screen using primary, Accepted 30 July 2016 mammalian spiral ganglion cultures in which we were able to detect a compound and others in its class Available online 2 August 2016 that increased neurite elongation, a critical step in restoring cochlear synapses after noise induced