(精选)【甲流H1N1精品课件】 Pandemic Influenza A (H1N1) Virology Update教学课件.ppt

A/Auckland/1/2009 A/South Carolina/10/2009 A/Mexico/10/2009 A/England/195/2009 A/New York/18/2009 A/California/4/2009 A/Texas/5/2009 California/7/2009 A/Nonthaburi/102/2009 A/Narita/1/2009 A/Delaware/3/2009 A/Texas/15/2009 ANTIGENIC MAPPING (CDC, 54 antigens; 16 sera) HI REACTIONS OF PANDEMIC INFLUENZA H1N1v VIRUSES (CDC) Vaccines and Related Biological Products Advisory Committee MeetingJuly 23, 2009Pandemic Influenza A (H1N1)Virology Update Nancy Cox, PhDAlexander Klimov, PhDInfluenza DivisionNational Center for Immunizations and Respiratory DiseasesCenters for Disease Control and Prevention Cases (n) First US Case April 15 RT-PCR kits to US labs 4/29 – 5/3 Kits to 233 US and 386 International labs by 6/12 Vaccine candidates shipped to manufactures BEGINNING OF THE 2009 H1N1 PANDEMIC Garten, et al. Science Express 2009 HOST AND LINEAGE ORIGINS FOR THE GENE SEGMENTS OF THE 2009 A(H1N1) VIRUS 1930 Slide courtesy of Dr. Amy Vincent, NADC, USDA REASSORTANT EVENTS AMONG SWINE INFLUENZA VIRUSES (SIV)IN NORTH AMERICA Classical Swine – N. American Lineage Eurasian Swine Lineage Avian – N. American Lineage Seasonal H3N2 PB2 PB1 PA HA NP NA MP NS 2009 H1N1 (swine/avian/human) PB2 PB1 PA HA NP NA MP NS Eurasian swine H1N1 PB2 PB1 PA HA NP NA MP NS N. Am. rH1N1 (swine/avian/human) ORIGIN OF THE 2009 PANDEMIC H1N1 VIRUS 07/21/09 #: Egg Isolate @: Oseltamivir Resistant H274Y Vaccine Candidates HA1 (H3 Numbering) April 2009 May 2009 June 2009 A/Hong Kong/2369/2009 Jun @ A/Rhode Island/04/2009 Jun A/Chile/2085/2009 Jun A/Jamaica/4423/2009 Jun A/Moscow/IIV03/2009 Jun A/Bermuda/4287/2009 Jun A/Michigan/10/2009 Jun A/Paraguay/28/2009 Jun A/New York/18/2009 Apr # A/Utah/10/2009 Jun A/Singapore/ON362/2009 Jun A/Philippines/2009/2009 May A/Victoria/2004/2009 May A/El Salvador/351/2009 May A/Ohio/07/2009 Apr # A/Singapore/ON226/2009 Jun A/South Australia/2001/2009 May A/Nanjing/1/2009 Jun A/Sao Paulo/2303/2009 Jun A/Colombia/394/2009