(精选)Antiatheroscleotic drugs教学课件.pptVIP

Part 5 Antiatheroscleotic drugs Plasma lipids Cholesterol free cholesterol (FC) cholesterolester (CE) Triglyceride (TG) Phospholipid (PL) Plasma lipoproteins Apoprotein (apo) Lipoprotein (apoprotein + lipids) Chylomicron (CM) Very low density lipoprotein (VLDL) Low density lipoprotein (LDL) Intermediate density lipoprotein (IDL) High density lipoprotein (HDL) Lipid metabolism in the body exogenous endogenous Drugs used in treatment of atheroscleosis 1. Lipid-regulating drugs（调血脂药） 2. Antioxidants（抗氧化药） 3. Polyunsaturated fatty acids (PUFAs) （多不饱和脂肪酸） 4. Protective agents for arterial endothelium（动脉内皮保护药） Drugs used in treatment of atheroscleosis Lipid-regulating drugs HMG CoA reductase inhibitors (statins): lovastatin（洛伐他汀）, etc. Inhibitors of intestinal sterol absorption: Bile acid binding resins (胆酸结合树脂): colestryramine（考来烯胺）, colestipol（考来替泊） Inhibitor of cholesterol absorption: ezetimibe (依泽替米贝) Nicotinic acids (烟酸类): nicotinic acid（烟酸）, acipimox （阿西莫司） Fibric acids (贝特类，苯氧酸类): gimfibrozil（吉非贝齐）, benzafibrate (苯扎贝特), etc. Drugs used in treatment of atheroscleosis HMG CoA reductase inhibitors （HMG CoA: 3-hydroxy-3-menthylglutaryl-coenzyme A, 3-羟基-3-甲基-戊二酸单酰辅酶A, 羟甲基戊二酰辅酶A） Lovastatin 洛伐他汀 Simvastatin 辛伐他汀 Pravastatin 普伐他汀 Fluvastatin 氟伐他汀 Mevastatin 美伐他汀 Atorvastatin 阿伐他汀 Cerivastatin 西立伐他汀 HMG CoA reductase inhibitors Drugs used in treatment of atheroscleosis (2) Other effects: inhibiting hypertrophy of arterial smooth muscles, inflammation, free radicals protecting vascular endothelium Actions of HMG CoA reductase inhibitors on cholesterol biosynthesis Lipid-lowing effect Other effects via modulating signal transduction 甲羟戊酸 鲨烯 类异戊二