(精编)【医学课件】 Th1Th2细胞因子在感染中的意义教学课件.pptVIP

更多医学精品尽在医学吧 /rayshiu Th1/Th2细胞因子在感染中的意义 浙江大学附属儿童医院 细胞因子 由免疫系统细胞以及其他类型细胞主动分泌的一类小分子量的可溶性蛋白质。包 括淋巴因子、干扰素、白介素、肿瘤坏死因子、趋势化因子和集落刺激因子等。 是免疫系统细胞间，以及免疫系统细胞与其他类型细胞间联络的核心，通过与细 胞特异的膜受体相互作用，能改变分泌细胞自身或其他细胞的行为或性质。 Th1/Th2 profile in our hospital IL-2, IL-4, IL-6, IL-10, TNF-a and IFN-r in the sera. the cytometric bead assay (CBA) Human Th1/Th2 Cytokine kit II (BD Biosciences, San Jose, CA, USA). Results from current data During infection and infection controlled The median levels of IL-4, IL-6, IL-10, TNF-a and IFN-r in febrile patients before antibiotic therapy were 3.9, 660.1, 122.7, 6.9 and 11.4 pg/mL, respectively. The interval between the two detections was 5.5 (2–24) days. Returned to 3.3, 22.8, 9.6, 4.1 and 6.4 pg/mL, respectively, after infection was controlled. Between the G+ and G? BacterialSepsis IL-6, IL-10, and TNF-a levels in patients with G? bacterial infection were higher than those in patients with G+ bacterial infection. The IL-6, IL-10, and TNF-a of G? group were 525.4 (10.2 to 5,000), 96.0 (7.0 to 5,000), and 6.9 (2.5–4263.4) pg/ml, respectively, which were all significantly higher than those of G+ group (150.0 (8.5 to 5000), 22.6 (3.4–2813.7), and 4.5 (2.5–81.6) pg/ml (P0.001), but the IL-2, IL-4, and IFN-r levels were comparable between the two groups (P0.05). In Hemophagocytic Lymphohistiocytosis (HLH) In HLH patients, IFN-r and IL-10 levels were significantly elevated and IL-6 levels were moderately elevated, but in MDI patients, IL-6 levels were much higher (usually 1000.0 pg/mL) than in HLH patients (60/145 (41.4%) vs. 2/43 (4.7%); p 0.001); IL-10 levels were highly elevated in patients with HLH and MDI diseases, but the rate in HLH cases (21/43 (48.8%) with high levels of IL-10 (1000.0 pg/mL)) was significantly higher than that (17/145 cases (11.7%); p 0.05) in MDI patients. The IFN-r levels in the EBV and CMV infection groups were slightly higher than those in the bacterial infectious group, but no significant differences were i