蛋白质组学及其在肾脏病研究中的应用幻灯片.pptVIP

This study was aimed at the search of urinary biomarkers which might help to predict the clinical response of IgA nephropathy (IgAN) patients to angiotensin converting enzyme inhibitors (ACEi). First, we studied the urinary proteome of 18 IgAN patients (toward 20 healthy controls) who had been chronically treated with ACEi by using 2-D PAGE coupled to nano-HPLC-ESI-MS/MS analysis. We identified 3 proteins, kininogen（激肽原） (p = 0.02), inter-alpha-trypsin-inhibitor heavy chain 4 (35kDa fragment) (p = 0.02) and transthyretin（甲状腺素转运蛋白）(p0.0001), whose urinary excretion was different in IgAN pati