转录后基因沉默 Posttranscriptional Gene Silencing案例实例.pptVIP

转录后基因沉默 Posttranscriptional Gene Silencing案例实例.ppt

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from Wu and Morris, Curr.Opin.Genet.Dev. 9, 237 (1999);from Wu and Morris, Curr.Opin.Genet.Dev. 9, 237 (1999);from McManus and Sharp, Nature Rev.Genet. 3, 737 (2002);The lin-14 Mutant has an Altered Pattern of Cell Division;Triggers of RNAi-Mediated Gene Silencing in Mammals;from Chen and Rajewsky, Nature Rev.Genet. 8, 93 (2007);Strand Selection Into the RISC;from Li and Hannon, Nature Rev.Genet. 5, 522 (2004);Strand Selection of Processed siRNA into the RISC ;Guide RNA Loading Onto Argonaute;The Fate of mRNA Loaded With the miRISC;Overview of RNA-Mediated Gene Silencing;Regulation of siRNA Levels in C. elegans;At least 800 miRNA-encoding genes in humans;Human Accelerated Regions;The Role of miRNA in Cancer;Loss of miR-126 and miR-355 when human breast cancer cells develop metastatic potential;from Steeg, Nature 449, 671 (2007);Immunostimulatory Effects of dsRNA;DNA Vector-based RNAi;from Mittal, Nature Rev.Genet. 5, 355 (2004);from Mittal, Nature Rev.Genet. 5, 355 (2004);from Dykxhoorn and Lieberman, Cell 126, 231 (2006);from Rossi et al., Nature Biotechnol. 23, 682 (2005);Alphavirus-mediated RNAi;RNAi-dependent Chromatin Silencing in S. pombe;Small RNAs Modulate Viral Infection;from Sarnow et al., Nature Reviews Microbiol. 4, 651 (2006);from Sarnow et al., Nature Reviews Microbiol. 4, 651 (2006);from Gupta et al., Nature 442, 82 (2006);from Sarnow et al., Nature Reviews Microbiol. 4, 651 (2006);Features of piRNAs;Model for Biogenesis of piRNAs that Target Mobile Elements;;Non-specific siRNA Inhibition of Angiogenesis;from Makeyev and Maniatis, Science 319, 1789 (2008);from Technau, Nature 455, 1184 (2008);EZH2 overexpression promotes cell proliferation

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