小剂量马普替林辅助治疗老年不稳定型心绞痛的疗效观察.pdfVIP

海南医学院学报 2009，15(10) 1240 JournalofHainanMedicalCollege 小剂量马普替林辅助治疗老年不稳定型心绞痛的疗效观察 刘志勇，吴 宁，李武雄 (解放军 187医院，海南 海 口 571159) [摘要]目的：探讨小剂量抗抑郁药辅助治疗老年不稳定心绞痛的疗效观察。方法：选择 179例 已确诊 的不稳定心绞痛患者做常规和动态心电图检查后，抑郁状态的诊断运用抑郁 自评量表 (SDS)，得分50 分以上者 102人入组，随机分成抗抑郁治疗组(53例)及对照组(49例)。对照组执行常规不稳定型心 绞痛的药物治疗，治疗组在常规治疗基础上加抗抑郁治疗，马普替林 12．5mg，2次／d(中午、睡前服)， 随访8周。结果：治疗组与对照组 比较，心肌缺血 明显改善 (P0．05)，心绞痛发作次数降低 (P 0．05)。结论：对不稳定性心绞痛伴抑郁情绪的老年患者行小剂量抗抑郁药治疗 比常规心绞痛治疗疗 效好 [关键词]心绞痛 ，不稳定型；抗抑郁药；马普替林；老年人 [中图分类号]R541．4 [文献标识码]B [文章编号]1007—1237(2009)10—1240-02 Effectofantidepressanttreatmentontheelderlyunstableanginapectorispatientswith emotionaldisorder LIU Zhi·yong．WU Ning．LI Wu—xiong (187MilitaryCentralHospitalHaikou571159，China) [FoundationProject]：HainanMedicalCollegeScientfiicResearchFundSupportedProjectoftheJournal(O(F2flY~190) [Author]：LIUZhi—yong(1975一)，Male，QiyangHunan，AttendingPhysician， B．Tel Email：gbbflzy@163．com Received：2009—08—20 Accepted：2009—0916 JHMC，2009；15(10)：1240—1241 View from specialist：Itiscreative，andofcertain scientificand educationalvalue· [ABSTRACT]Objective：Tostudytheeffectsofantidepressanttreatmentontheelderlyunstableangina pectorispatientsaccompaniedwithemotionaldisorder．Methods：Examined179 eldercaseswithunstableangina pectorispatientsaccompaniedwithemotionaldisorderbyroutinetestanddynamicelectrocardiogram，anddiagnosed thedepressionstatusbySDS．Selected 102 caseswithhigherthan50 scoresinSDStest，andrandomlydivided them intotreatmentgroupandcontrolrgoup．Treated53patientsintreatmentgroupbystandardroutinetreatmentas wellasanti．depressiontreatmentwithMaprotiline12．5mg，twiceaday，whilethecontrolgroupbystandardrou— finetreatment．Theywereallfollowedupfor8weeks．Results：Comparedwiththecontrolgroup，myocardialische— miawasimprovedsignificantly，andtheattacktimesofanginapectoriswereless(P0．05)．Conclusion：Treat— mentwithsmal1．dosageofantidepressa