AIIA在糖尿病肾病预防与治疗.ppt

Slide 5 RENAAL Enrollment by Region Patients were enrolled in RENAAL from four regions e.g. North American, Latin American (Central and South), Europe and Asia1. Seventeen percent of the RENAAL patients were from Asian countries including China-Hong Kong, Japan, Malaysia and Singapore3. References 1. Brenner BM, Cooper ME, de Zeeuw D et al for the RENAAL Study Investigators The losartan renal protection study – rational, study design and baseline characteristics Of RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) JRAAS 2000;1:328-35 3. Chan JCN, Wat NMS, So W-Y et al on behalf of the Asian RENAAL Study Investigators Renin angiotensin alsosterone system blockade and renal disease in patients with type 2 Diabetes Diabetes Care 2004;27:874-9. RAAS Blockade and Renal Disease in Type 2 Diabetic Patients: An Asian Perspective from the RENAAL Study (Asian subgroup post-hoc analysis) A total of 252 Asian patients were enrolled in the RENAAL Study, which compared losartan (50 mg titrated to 100 mg) to placebo in addition to conventional antihypertensive medications in type 2 diabetic patients with nephropathy. The effect of losartan therapy on renal and cardiovascular outcomes was examined, and baseline predictors of risk were determined using a Cox proportional hazards model3. Reference 3. Chan JCN, Wat NMS, So W-Y et al on behalf of the Asian RENAAL Study Investigators Renin angiotensin alsosterone system blockade and renal disease in patients with type 2 Diabetes Diabetes Care 2004;27:874-9. Slide 12 RENAAL: Baseline Clinical Characteristics of the RENAAL Study: Asian (post-hoc analysis) and Main Study Populations This table presents some of the key baseline characteristics of the Asian and Main study populations. The baseline characteristics of the two cohorts were quite similar for all parameters except Body mass index which was lower in the Asian Subgroup2,3. References 2. Brenner BM, Cooper ME, de Zeeuw D et al for t