脑卒中后抑郁患者前扣带回海马灰质体积基于体-第三军医大学学报.DOCVIP

脑卒中后抑郁患者前扣带回、海马灰质体积磁共振成像研究 吴 磊1,吴 文1,曾 庆1,赵一瑾1,杨建明2(510282广州，南方医科大学珠江医院：康复医学科1，影像诊断科2) [摘要] 目的：探讨脑卒中后抑郁(post-stroke dpression, PSD)患者是否存在双侧海马、前扣带回灰质体积下降及灰质体积改变是否与抑郁严重程度的相关。方法：13例脑卒中后抑郁患者（PSD组）和18例脑卒中后无抑郁患者(non-PSD组)接受3D高分辨率T1WI磁共振扫描，采用VBM-DARTEL方法对扫描获得的结构图像进行预处理，并将双侧海马及前扣带回作为感兴趣区（region of interest，ROI），最后用双样本t检验比较PSD组与non-PSD组组间灰质体积差异。结果：与non-PSD组相比，PSD组患者双侧前扣带回(体素200)及双侧海马(左侧体素200，右侧体素200)体积下降差异具有统计学意义(P＜0.001，未校正)，未发现灰质体积显著增加的区域。在PSD组中，显著下降的灰质体积与汉密尔顿抑郁量表(Hamilton depression scale, HAMD)评分及抑郁持续时间无显著相关关系(与HAMD评分相关：r左侧海马=0.356,r右侧海马=0.24,r双侧前扣带回=0.343；与抑郁持续时间相关：r左侧海马=0.452, r右侧海马=0.413，r双侧前扣带回=0.379，P 0.05)。结论：与原发性抑郁相似，卒中后抑郁患者也存在海马和前扣带回灰质体积下降，但海马和前扣带回灰质体积下降与抑郁严重程度无显著相关。 [关键词] 脑卒中后抑郁；灰质体积；海马；前扣带回；磁共振成像；形态测量学 Magnetic Resonance Imaging Analysis on grey matter volume of the anterior cingulate and hippocampus in patients with post stroke depression Wu Lei1, Wu Wen1, Zeng Qing1, Zhao Yijin1, Yang Jianming2 (1Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282; 2Department of Rediology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China) [Abstract] Objective: Our goal was to determine whether patients with PSD also exist decreased gray matter volumes in the hippocampus and anterior cingulate cortex(ACC), whether gray matter volume changes significantly associate with symptom severity. Methods: Thirteen patients with PSD and eighteen patients without PSD underwent examination of three-dimensional high-resolution T1 weighted MRI, voxel-wise analyses of regional gray matter volume were conducted by the VBM analysis using DARTEL algorithm in SPM8, And select the bilateral hippocampus and anterior cingulate As aregions of interest. Two-sample t-test and partial correlation analysis was used for statistical analysis. Results：Compared with the non-PSD patients, the PSD group showed significantly lower gray matter volume in bilateral anterior cingulate (P 0.001, voxel＞200) and bilateral hippocampus (P 0.00