99mtc奥曲肽spectct受体显像对小细胞肺癌化疗前后疗效观察的研究 word格式.docxVIP

3、99mTc-OCT SPECT/CT 受体显像 TC/NC 比值是评价 SCLC 化疗效果更精准、更经 济有效的方法，对预测 SCLC 化疗疗效具有指导价值。硕士研究生： 李超 （放射医学） 指导教师： 左书耀教授关键词：肺肿瘤, 小细胞肺癌；化学治疗；奥曲肽，生长抑素受体；99m 锝，核素显像；SPECT/CT 断层显像The evaluation of the chemotherapy in SCLC with 99mTc-octreotide SPECT/CT receptor scintigraphyAbstractObjective To observe the primary tumor and its metastases in small cell lung cancer with 99mTc-octreotide SPECT/CT receptor scintigraphy and to evaluate the clinical value of the early chemotherapy of the small cell lung cancer.Methods 22 patients with a histological diagnosis of SCLC without surgical treatment were performed with 99mTc-octreotide SPECT/CT imaging before the chemotherapy and after the 2 cycles of chemotherapy, respectively. CT examination was performed during this period, within the interval of 1 weeks. Primary tumors and metastasis were detected with 99mTc-octreotide SPECT/CT imaging before therapy. The uptake of 99mTc-octreotide of primary tumors, metastasis lymph nodes and distant metastases in 22 cases of SCLC were observed before and after chemotherapy. The primary tumors were divided into high uptake group, moderate uptake group, and mild uptake group with 99mTc-octreotide imaging, and narrow diameter 2 cm group, narrow diameter 2 cm group, diameter increase group and no change group with CT. Tumor to normal tissues ratios(T/N) were observed using ROI(region of interest), and the T/N ratio was compared with CT size before and after chemotherapy of primary tumor in 22 cases of SCLC.Results 28 primary tumors, 27 metastasis lymph nodes and 7 distant metastases were detected in 22 SCLC with 99mTc-octreotide SPECT/CT imaging before chemotherapy, and the sensitivity of them were 93.33%, 60.00%, and 77.77% respectively. The uptake level of 99mTc-octreotide in primary tumors and metastasis lymph nodes were mainly moderate, while distant metastases were mild before chemotherapy; after therapy, the former turned into mild intake, while no obvious change was found in distant metastases. T