秦艽不同配伍对风寒湿痹与风湿热痹模型大鼠作用性-效关系实验研究-中药学专业论文 word格式.docxVIP

好，秦艽配桑寄生（平平相配）次之，单味秦艽、秦艽配羌活（平温相配）、秦艽配威灵仙（平温相配）作用更次。说明中医临床“辨证施治”，“热证用寒药，寒证用热药” 的治疗原则是科学有效的。其次本实验还发现各配伍组疗效与药物本身作用强弱有一定关系，在二种不同环境中，秦艽配伍羌活组显现出较好的抗炎、镇痛及解热作用。关键词：秦艽；配伍；风寒湿痹；风湿热痹；性效关系；实验研究ABSTRACTAbstract:ThroughtheapplicationofdifferentmatchofG.macrophyllawithL.Merr,Incised Notopterygium,Radix Clematidis,RadixFangchirespectivelytothemodelrat with wind-cold-dampnessarthralgiaorwind-dampness-heatarthralgia,thestudydiscussedthe relationshipbetweennatureandeffectofthematches,betweennature andefficiency.Through thedimethylbenzene-causedauricleswollenandcapillarypenetrationchangemodel,icy aceticacid-causedbody-wrenchingandtail-swingpainmodel,theanti-inflammationandpain-killing effect of G. macrophylla and its match is studied; through 2，4-dinitrophenol-causedratfevermodelandrat’sbodytemperatureindifferenttime,thefever releasingfunctionofG.macrophylla’sdifferentmatchisresearched.Thefeverreleasing functionofallthematchofG.macrophyllaisobviously betterthanthatofsingleG. macrophylla.Amongthematchgroups,G.macrophyllaplusRadixFangchiisbest,thenG. macrophyllaplusL.MerrG.macrophyllaplusRadixClematidisG.macrophyllaplus IncisedNotopterygium.Throughthemimickingofhuman’sarthralgiacause, wind-cold-dampnessarthralgiamodelandwind-dampness-heatarthralgiamodelare established,andtheirswollenrate,painthreshold,serumTNF-a,IL-1β,indexofthymusand spleenhadbeenexamined,theanklearticulationofthetwohindlegshadbeenXfilmedand thetissueofanklearticulationhadbeenobserved.Tothewind-cold-dampnessarthralgia,the threegroupsofG.macrophyllaplusL.Merr,G.macrophyllaplusRadix Clematidis, G. macrophyllaplusIncisedNotopterygiumcanobviouslyinhibitswollensoleoflefthindfoot, raise theweight carryingindexof left foot, reducethe indexes of thymusand spleen aswell as TNF-αandIL-1βlevel.XfilmshowsG.macrophyllaplusIncisedNotopterygiumgroupcan obviouslyimproveanklearticulationpathologicalchange.TissueobservationshowsG. macrophyllaplusIncisedNotopterygiumgroupand.G.macrophyllaplusRadixClematidis groupcanobviouslyimp