临床医学牟教授赛诺菲患者教育幻灯.pptVIP

* * 联合治疗比单药治疗具有更快的降压作用1 在双盲治疗的所有时间点，厄贝沙坦 / HCTZ 联合治疗组 SeDBP 与基线相比的血压下降幅度都大于厄贝沙坦单药治疗组。1 联合治疗组在第 3 周时已使 SeDBP 下降超过20mmHg，而单药治疗组直至第 7 周仍未达到相似的下降幅度。 参考文献 Neutel JM et al. Efficacy and safety of Irbesartan/ HCTZ combination therapy as initial treatment for rapid control of severe hypertension. J Clin Hypertens 2006;8:850–857. * * 研究中，联合治疗组血压达标患者显著更多 厄贝沙坦 / HCTZ 联合治疗在双盲治疗的每一周其坐位收缩压 (SeSBP) 和坐位舒张压 (SeDBP) 得到控制的病人比例，都显著大于单药治疗组（每一时间点 P0.0001）。两组在第 5 周时，按JNC 7 指南标准血压得到控制的病人比例也存在显著差异（联合治疗组34.6%，单药治疗组19.2%，P0.0001）。到第 7 周时病人比例分别上升至 37.8% 和 21.4%（P0.0001）。 参考文献 Neutel JM et al. Efficacy and safety of Irbesartan/ HCTZ combination therapy as initial treatment for rapid control of severe hypertension. J Clin Hypertens 2006;8:850–857. * * 安博诺治疗中国高血压患者的的达标率分析结果显示：安博诺治疗8周降压达标率超过94% 。如图中所示，安博诺治疗2周，即有78%的患者治疗达标，治疗第4周时，88%的患者治疗达标，至治疗第8周时，患者的降压达标率超过94% * 安博诺不仅降压疗效极佳，而且不良反应发生率也很低，只有6.71%。所有的不良反应都是轻微的，没有患者因不良反应而停药，也没有发现因用药剂量的增加，不良反应也增加的情况。低血钾发生率仅为0.4%。 * 依思汀（贝那普利氢氯噻嗪片），首个以贝那普利为核心的、联合利尿剂的单片复方制剂，能有效针对高盐摄入，强效降压，保护靶器官。 * Abbreviations Ang I = angiotensin ACE = angiotensin converting enzyme ACEI = angiotensin converting enzyme inhibitor ARB = angiotensin receptor blocker AT1 = type 1 angiotensin II receptor RAAS = Renin-angiotensin-aldosterone system Reference Müller DN, Luft FC. Direct renin inhibition with aliskiren in hypertension and target organ damage. Clin J Am Soc Nephrol 2006;1:221–8. * Eleven-week-old DS rats fed an 8%-NaCl diet received either vehicle or imidapril (1 mg/kg per day) for 7 weeks. The renal expression of the NAD(P)H oxidase p47phox and endothelial NO synthase were evaluated. In DSHF rats, associated with increased renal angiotensin II, mRNA and protein expression of NAD(P)H oxidase p47phox were enhanced with an increase in renal lipid peroxidation production (0.330.03 versus 0.220.01 nmol/mg protein, P0.05) and urinary excretion of hydrogen peroxide (26.96.6 versus 9.52.1 U/mg creatinine, P0.01) compared with levels in Dahl salt-resistant rats. The endothelial NO s