学习与记忆-微观2-4-3 [兼容模式].pdfVIP

OutlineOutline 1. Thee basbasicc coconcepceptss oof leaearninggmeemooryy classification of learningmemory bbraiin sttructtures hhostiting llearniingmemory learningmemory in behavioral study llearniingmemory andd neurall pllastiticitity 2. The molecular basis of learning memory studies in Aplysia studiesstudies inin mousemouse, LTPLTP, LTDLTD andand longlong termterm memorymemory • Aplysia ： habituationhabituation sensitization associative learning • Vertebrates:Vertebrates: LTPLTP andand LTDLTD • Molecular mechanism of LTM Invertebrate Nervous Systems Show Plasticity-Aplysia HHabitbituatition iin AApllysiia: Squirts of water on its sipphon causes it to retract its gill. AfterAfter repeatedrepeated squirtssquirts, thethe animal retracts the gills lessless – itit hashas learnedlearned thatthat the water poses no dangerdanger. Where the change underlying hhabitbituatition occur • at the sensory nerve endings in the skin, making them less sensitivesensitive toto thethe squirtsquirt ofof water;water; • at the muscle, making it less responsiveresponsive toto synapticsynaptic stimulation by the motor neuron; • atat thethe synapsesynapse betweenbetween thethe sensory neuron and the motor neuron. Repeated electrical stimulation of a sensory Neuron leads to a pproggressivelyy smaller EPSP