full-field calcium k-edge x-ray absorption near-edge structure spectroscopy on cortical bone at the micron-scale polariz.细致的钙k-edge x射线吸收靠近边缘结构光谱在微米尺寸极精品.pdfVIP

Article pubs.acs.org/ac Full-Field Calcium K‑Edge X‑ray Absorption Near-Edge Structure Spectroscopy on Cortical Bone at the Micron-Scale: Polarization Effects Reveal Mineral Orientation Bernhard Hesse,*,† Murielle Salome,† Hiram Castillo-Michel,† Marine Cotte,†,‡ Barbara Fayard,†,○ Christoph J. Sahle,† Wout De Nolf,† Jana Hradilova, §, ∥ Admir Masic,⊥ Birgit Kanngießer,# Marc Bohner,△ Peter Varga,▽ Kay Raum,§ and Susanne Schrof§ †European Synchrotron Radiation Facility, CS40220, Grenoble 38043 Cedex 9, France ‡Sorbonne Universites, UPMC Univ Paris 06, CNRS, UMR 8220, Laboratoire D’Archeologie Moleculaire et Structurale (LAMS),́ ́ ́ Paris, France §ChariteUniversitatsmedizin Berlin, Berlin, Germaný ̈ ∥Czech Technical University in Prague, Faculty of Nuclear Science and Physical Engineering, 166 36 Prague 6, Czech Republic ⊥MIT, Department of Civil and Environmental Engineering, 77 Massachusetts Avenue, 02139 Cambridge, Massachussetts, United States #Technical University of Berlin, Institute for Optics and Atomic Physics, 10623 Berlin, Germany △RMS Foundation, CH-2544 Bettlach, Switzerland ▽AO Research Institute Davos, 7270 Davos, Switzerland ○LPS UMR8502 - Universite Paris, Sud-91405 Orsay, cedex - Francé S *Supporting Information ABSTRACT: Here, we show results on X-ray absorption near edge structure spectroscopy in both transmission and X-ray fluorescence full-field mode (FF-XANES) at the calcium K-edge on human bone tissue in healthy and diseased conditions and for different tissue maturation stages. We observe that the dominating spectral differences originating from different tissue regions, which are well pronounced in