法舒地尔对后循环 TIA血液流变学与血流动力学影响.docVIP

法舒地尔对后循环 TIA血液流变学与血流动力学影响 　　【中图分类号】R473.31；R992【文献标识码】A【文章编号】1003-8183-（2011)09-0059-02 　　【摘要】目的：观察法舒地尔治疗后循环短暂性脑缺血发作（TIA）的疗效及对血液流变学和血流动力学的影响。方法：将64例后循环TIA患者随机分为治疗组和对照组各32例，对照组予低分子肝素钙治疗，治疗组予低分子肝素钙和盐酸法舒地尔注射液治疗；观察两组临床疗效，监测患者血液流变学和后循环血流动力学指标。结果：治疗组总有效率 100.0 % ，明显高于对照组 87.5% P＜ 0. 05(χ2=4.267)，和对照组比较，治疗组血液黏度降低，红细胞沉降率减慢，经颅多普勒( TCD)观察到治疗组在治疗后平均流速(V m ) 、血管搏动指数(PI)有显著改善( P＜ 0. 01) 。结论： 法舒地尔注射液治疗后循环短暂性脑缺血发作安全、有效，能明显改善患者的血液流变学和血流动力学指标。 　　【关键词】短暂性脑缺血发作；后循环；法舒地尔；血液流变学；血流动力学 　　 The Influence of Fasudil on Hemorrheology and Hemodynamics in the Treatment of Transcient Ischemia Attack of Posterior Circulation 　　 Hu Wuhui1 ，Ding ling2 　　【Abstract】Objective：To observe the therapeutic effect of fasudil in the treatment of transcient ischemia attack(TIA) of posterior circulation and its influence on hemorrheology and hemodynamics. Methods： 64 patients with posterior circulation TIA were randomly divided into treatment group and control group 32 patients in the control group were treated with low molecular weight heparin therapy in the treatment group to the low molecular weight heparin and fasudil hydrochloride injection in the treatment； were observed Clinical monitoring of patients after the circulation of hemorheology and hemodynamics. Results： The total effective rate of 100.0%， significantly higher than 87.5% P＜0. 05 (χ2 = 4.267)， and the control group， treatment group decreased blood viscosity， erythrocyte sedimentation rate and transcranial Doppler (TCD) was observed after treatment in the treatment group average velocity (V m)， vascular pulsatility index (PI) was significantly improved (P＜0. 01)Conclusion： Fasudil is a safe and effective drug for the treatment of TIA of posterior circulation and can effectively improve the indices of hemorrheology and hemodynamics. 　　【Key words】 Transcient ischemia attack， Posterior circulation； Fasudil； hemorrheology； 　　 　　后循环（即椎-基底动脉系统）短暂性脑缺血发作（TIA）是临床常见的急性病，是后循环脑梗死主要危险因素之一，控制其发作是预防和推迟后循环脑梗死发生的重要措施之一。法舒地尔（川威）是一种新型蛋白激酶（Rho激酶）的抑制剂，能扩