血脂康联合辛伐他汀对冠心病患者血脂与C-反应蛋白影响.docVIP

血脂康联合辛伐他汀对冠心病患者血脂与C-反应蛋白影响 　　【中图分类号】R541.4；R972.+6 【文献标识码】A【文章编号】1003-8183-（2011)09-0003-02【摘要】目的： 探讨血脂康联合辛伐他汀对冠心病患者血清中血脂和C-反应蛋白(CRP)的影响。方法：收集2008年3月至2009年9月我院住院的冠心病患者40例，按随机数字表分为常规组(20例)和治疗组(20例)，选择同期健康老年人作对照组(20例)；常规组服阿司匹林0.1，1次/d，辛伐他汀10mg，1次/d，单硝酸异山梨酯40mg，1次/d，发作时加用硝酸甘油10mg与5%葡萄糖250mL静滴。治疗组于常规组基础上加服血脂康血脂康0.6g，2次/d。对照组服维生素B210mg，3次/d；治疗前和实验结束后第2d空腹抽取静脉血3ml离心，留取血清备测血脂和CRP浓度。结果：常规组和治疗组治疗前血清中TG、TC、LDL-C和CRP浓度均高于对照组，HDL-C浓度低于健康对照组，差异均有显著性；常规组和治疗组治疗后血清中TG、TC和LDL-C浓度均降低，而HDL-C浓度升高，以治疗组幅度更大，但降低的各项指标仍高于对照组，而升高指标仍低于对照组，仅治疗组中TC、LDL-C和HDL-C差异无显著性。各组治疗前后仅治疗组中TC、LDL-C、HDL-C和CRP浓度及常规组中HDL-C和CRP浓度差异有显著性。常规组和治疗组治疗后仅TG差异无显著性。结论：血脂康可能协同辛伐他汀上调冠心病患者血清中HDL-C浓度，下调TC、LDL-C和CRP浓度，抑制炎症反应。 　　【关键词】冠心病；血脂；C-反应蛋白；血脂康；辛伐他汀 　　 Effect on Serum Lipids and CRP of Coronary Heart Disease with Xuezhikang Joint Simvastatin 　　 Song chibo， Xu Lijiao，Ou Yangxiang. 　　【Abstract】Objective：Explored effects on serum lipids and CRP of coronary heart disease with Xuezhikang the joint simvastatin Method： Collected coronary heart disease patients in our hospital，from March 2008 to September 2009. 40 patients were randomly divided into conventional group (20 cases)and treatment group (20 cases)，and choosed the healthy elderly over the same period as the control group (20 cases ). the conventional group Aspirin 0.1，1 times/d， Xin statin 20mg， 1 times/d， isosorbide mononitrate 40mg， 1 times/d， attack plus 10mg nitroglycerin and 5% glucose 250mL Intravenous drip. the treatment group were added services on the basis of the conventional group Xuezhikang 0.6g?? 2 times/d. the control group vitamins B210mg， 3 times/d. Treatment before and after end of the experiment 2d collected fasting blood 3ml centrifuge to test serum lipid and CRP levels.Results： Conventional group and treatment group pre-treatment on serum TG， TC， LDL-C and CRP levels were higher，HDL-C levels were lower than healthy control group，and the differences were significant，respectively. Conventional group and treatment group after treatment on serum