遗传流行病学fudanuniversity.pptVIP

Fuchaowei Dept of Epi The introduction of genetic epidemiology a discipline closely allied to traditional epidemiology that focuses on the familial, and in particular genetic, determinants of disease and the joint effects of genes and non-genetic determinants. -PR Burton et al, Lancet 2005 Familial Aggregation Table 1. Conventional CS-CN approach Table 2. Family CS-CN approach Heritability Heritability Holzinger: Falconer： h2=r (2r, 4r and 8r for first, second and third degree of relatives, respectively ) Segregation analysis Segregation analysis for “simply diseases” Segregatio