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血吸虫病和激动肠炎诊断和流行病学tools.ppt

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血吸虫病和激动肠炎诊断和流行病学tools

* The Association of Schistosomiasis and Inflammatory Bowel Disease with Colorectal Cancer: Tools for Diagnosis and Epidemiology Peter Chun, Ph.D * In Egypt, schistosomiasis ( from S. haematobium and mansoni)has been strongly linked to bladder cancer. The evidence includes: Epidemiological evidence Experimentally induced schistosomiasis Histopathology Age and gender ratios M. H. Mostafa et al. Relationship between Schistosomiasis and Bladder Cancer. Clin Microbiol Rev 1999. 12(1)97-111 The evidence linking S. manosini haematobium infection to cancer of the large intestine is scant, but intestinal infestation with S. japonicum is considered a significant contributory factor to the development of cancer of the colon and rectum. A. Ishii et al. Parasitic infection and cancer: with special emphasis on Schistosoma japonicum infections (Trematoda). A review. Mutat Res. 1994 305(2)273-81 * Colorectal cancer correlates with prevalence and intensity of shistosome infection. The age of onset of cancer is lower in areas of shcistosome endemicity and length of survival is shorter. Affected individuals usually have a long history of inflammatory large bowel symptoms. The cancers correspond in anatomic location to the area most affected by the parasite. Z. Xu et at. Schsitosoma japonicum and colorectal cancer: an epidemiological study in the People’s Republic of China. Int J Cancer. 1984. 34(3):315-8 C. Ming-Chai et al. Evolution of colorectal cancer in schistosomiasis: transitional mucosal changes adjacent to large intestinal carconoma in colectomy specimens Cancer 1980. 46(7):1661-75 Chen et al. Colorectal cancer and schistosomiasis. Lancet 1981 971-3 ES. Zhao et al. Carconoma of the large instestine with schistosomiasis—analysis of 279 cases. Zhonghua Zhong Liu Za Zhi. 1981 3(1):67-9 ES Zhao. Cancer of the colon and schistosomiasis. J R Soc Med. 1981 74(9):645 K. Shindo. Significance of schistosomiasis japonica in the development of cancer of the large intestine. Dis C