冠心病患者血浆脂连素和补体c3表达的有关性.pdf

冠心病患者血浆脂连素和补体C3 表达的有关性 【摘要】目的：探讨冠心病患者血浆脂联素和补体C3 水平的变化及其关系. 方法： 冠心病患者35 例，其中稳定型心绞痛( SAP )16例，不稳定型心绞痛 ( UAP )19例；年龄、性别、体质量与其匹配的健康对照24 例. 用酶联免疫法 测定血浆脂联素的浓度，用免疫散射比浊法测定血清补体C3 浓度，并分析两者 浓度在冠心病中的变化及其关系. 结果： UAP 组血清补体C3 水平明显高于健 康对照组［（1.59±0.42）g/L vs （1.27±0.25）g/L， P＜0.05］，SAP 组 和UAP 组脂联素水平均显著低于健康对照组［6.62(1.19～15.50)， 4.97(1.07～14.80) mg/L vs 10.25 （4.51～28.23）mg/L， P0.05］；血浆脂 联素与补体C3、三酰甘油、体质量、腰围、腰臀比值呈负相关(P均＜0.05)； 补体C3 与三酰甘油正相关(P=0.000)，与脂联素负相关(P=0.041). 结论： 脂 联素水平降低和补体C3 水平升高可能是冠心病发生发展的重要因素；补体C3 的改变与脂联素水平负相关，提示脂联素的代谢可能影响补体C3 的表达. 【关键词】冠状动脉疾病；脂连素；补体C3 【Abstract】 AIM: To study the correlation between plasma adiponectin level and complement C3 expression in patients with coronary heart disease. METHODS: Thirty five consecutive patients with coronary heart disease were recruited in this study， among them 16 patients had stable angina and 19 had unstable angina; 24 healthy people matched in terms of age， sex and body mass served as controls. Plasma adiponectin level was tested with ELISA and serum C3 was tested with rate nephelometry. The relationships among plasma adiponectin， serum C3 and coronary heart disease were analyzed. RESULTS: Compared with healthy controls， serum level of C3 was increased significantly in the unstable angina pectoris group ［（1.59±0.42）g/L vs （1.27±0.25）g/L， P0.05］， while the plasma level of adiponectin was decreased significantly in the stable angina pectoris group and the unstable angina pectoris group ［6.62(1.19～ 15.50)， 4.97(1.07～14.80) mg/L vs 10.25 （4.51～28.23）mg/L， P0.05］. Plasma adiponectin level was negatively correlated with complement C3， triglycerides(TG)， body mass， waist circumference and waist hip ratio (P＜0.05）; complement C3 was positively correlated with TG （P＝0.000）， and negatively with adiponectin （P ＝0.041）. CONCLUSION: The levels of adiponectin and C3 might be closely related with the development of coronary heart disease; complement C3 is negativel