disc1在脑白质发育中的表达及其在胶质细胞中作用的初步分析word格式论文.docxVIP

缩略语表英文缩写CNPase英文全称2,3-cyclic nucleotide 3phosphodiesterase中文名称23-环核苷酸的 3磷酸二酯酶DAPI4,6-diamidino-2-phenylindole4,6 二脒基-2-苯吲哚盐酸DMSO ESFBSDimethyl sulphoxide Equine SerumFetal bovine serum二甲基亚砜马血清 胎牛血清GFAP GFPHRPGlial fibrillary acidic protein Green fluorescent proteinHorseradish peroxidase神经胶质原纤维酸性蛋白绿色荧光蛋白 辣根过氧化物酶MBP NG2ODMyelin basic protein Neuron-glial antigen 2Optical density髓鞘碱性蛋白神经元-神经胶质 2 型抗原 光密度值Oli-neu PCRPDGFRαOligodendroglial lineage cells Polymerase chain reactionPlatelet-derived growth factor receptor少突胶质细胞系聚合酶链式反应 血小板衍生因子受体 αPDL SDSTEMEDPoly-D-lysine Sodium dodecyl sulfateTtetramethylethylenediamine多聚赖氨酸十二烷基硫酸钠 四甲基乙二胺TrisHydroxymethyl aminomethane三羟甲基氨基甲烷Expression of DISC1 in Developmental White Matter and its Role in Glial CellsAbstractDisrupted-In-Schizophrenia 1(DISC1) has been considered to be one of the main predisposing factors for schizophrenia. DISC1 was initially identified in a large Scottish family with schizophrenia through a balanced chromosomal translocation (1;11)(q42.1;q14.3). Human DISC1 gene is located on chromosome 1 at q14.3 range, which includes 13 exons encoding 854 amino acids. The molecular weight of the protein is about 93.6KD. DISC1 protein contains multiple function domains, mediates more than 200 proteins interactions, and participates in many signaling pathways. Therefore, it is of great significance to study functions of DISC1 gene for the pathogenesis and clinical diagnosis and treatment of schizophrenia in central nervous system. Recent progress in the functions of DISC1 particular focuses on its roles in neurons. It has been shown that DISC1 is involved in the regulation of neuronal migration, axonal growth, synaptic transmission, control excessive integration of neurons during brain development and so on. Neuroglial cells, such as astrocytes (AST) and oligodendrocytes (OL), which own the greatest number in the brain, play an important role in neuroprotection, neurotrophic, neuro sustain and myelination. Effects of DISC1