dog1在胃肠间质瘤中表达的临床分析word格式论文.docxVIP

CD117，差异无显著性（P＞0.05）。4. 112例GIST中，CD34阳性77例，阳性率为68.8%，DOG1在GIST的诊断上优于CD34。5.DOG1不能作为GIST危险度分级的依据。关键词：胃肠间质瘤，DOG1，CD117，CD34，免疫组化ClinicalresearchofexpressionofDOG1ingastrointestinalstromaltumorsObjective:ToinvestigatethediagnosticvalueofDOG1ingastrointestinalstromaltumors(GIST)bydetectionofDOG1expression.Methods:Postoperativespecimensof112caseswithGIST,diagnostedby Diagnostic Criteria of the Chinese gastrointestinal stromal tumors,wereselectedfromAffiliatedHospitalofLuzhouMedicalCollege ,Subsidiary of Chinese Medicine Hospital of Luzhou MedicalCollegeandLuzhoupeople’sHospital,fromJanuary2009toDecember2011.The 34 casesofleiomyoma,30 cases ofnormal gastrointestinalmucosawereselected ascontrolgroup. ImmunohistochemicalEnvisiontechniquewasusedtoassesstheexpressionofDOG1in112casesofGIST in comparison with 34 cases ofLeiomyoma and 30 cases ofnormalgastrointestinalmucosa.Thejudgmentofpositiveexpressionwasthatyellow-browngranuleswasdetectedincellmembraneandcytoplasm.Results:（1）Of 112 GIST:①Age: 23-78，average age of（55.7±10.5），medianage58，21-30yearsoldin2cases(1.8%),31-40yearsoldin6cases(5.4%),41-50yearsoldin27cases(24.2%),51-60yearsoldin39cases(34.8%),61-70yearsold in 30 cases(26.8%),71-80yearsoldin8cases(7.1%);②sex:male61cases(54.5%),female51cases(45.5%);③site:51cases(45.5%)wasfoundinstomach,31cases(27.7%)wasfoundinintestine,30cases(26.8%)wasfound in parenteral position.④risk strstification of tumor (NIH riskclassificationofPrimaryGISTresection)：verylowrisk7case（s6.3%），lowrisk22cases（19.6%），risk37cases（33.0%），highrisk46cases（41.1%）；⑤Cytological classification:spindle cell type 76cases（67.9%），epithelioidcell type 25cases（22.3%），hybrid 11cases（9.8%）;(2)Positive expressionrateOf DOG1:GISTgroup:96.4%(108/112),leiomyoma group :only 1 of 34 cases,Gastrointestinalmucosal:0caseswaspositiveof30cases.ThespecificityofDOG1was98.4%。Of112GIST,DOG1expressionwasnotrelatedtothesex、age、site、theriskstrstificationoftumororcytologicalclassificationofthepatient,(P＞0.05).（4）Of112GIST：positi