基于生物信息学的虚寒证特征与证候分析流程-characteristics of deficiency-cold syndrome and syndrome analysis process based on bioinformatics.docx

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2018-05-20 发布于上海
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基于生物信息学的虚寒证特征与证候分析流程-characteristics of deficiency-cold syndrome and syndrome analysis process based on bioinformatics.docx

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基于生物信息学的虚寒证特征与证候分析流程-characteristics of deficiency-cold syndrome and syndrome analysis process based on bioinformatics

Results??34~37%peopleareaffectedbyDCPamongthetotalpopulationina13-yearaccumulativeepidemiologicstudyinPengzhou,Sichuan,mostlyhavingcombinationDCP(i.e.DCPthataffectingtwoormoreZang-organs).53%oftheaffectedhaveHeart-Spleen-KidneyYD,21%Spleen-KidneyYD,and12%Heart-KidneyYD.Fewerhaveone-ZangorganDCP,withKidneyDCPcontributingto5%ofthetotalaffected.PeoplewithKidneyDCPsymptomsandsigns,regardlessofone-ZangorganorcombinationDCP,contributeto93%ofthetotalDCPpopulation??Real-timeQ-PCRanalysisshows:1).NDUFV1,NDUFA1,ATP6V0D1,ATP5C1andATP4Ahavehigherexpressionamongexperimentgroup;2)ENO1andP2RX5havelowerexpression,withthelatterasrepetitivetest;3)ACLY,GAPDHandCYC1donotshowobviousdifferenceamongthetwogroups;4)TtestshowsstatisticsignificancebetweenthetwogroupsregardingATP6V0D1andATP4A??DesignedandbuiltaprocessframeworkforTCMPattern-BioinformaticsStudy,includingtheblueprintoftheoverallmodelanddisseminatedprocesssteps,accompaniedwithverbaldescriptionandexplanationConclusion??Samplingofpracticalmethodology—demonstrationofcomprehensivedataprocessingmethodologyforTCMPattern-BioinformaticsresearchItisthekeytochoosetherightsetofmethodsinsolvingthepuzzlementbroughtwithtremendousamountofdata.Atthesametime,itraisesmoreconfusionwiththeintroductionofdiverseanalyzingtoolsandsoftware.Massivedatacanbetranslatedintousefulinformationonlywiththecorrectsetofprocessingtheanalyzingtools,providingfeasibilityforTCMPattern-BioinformaticsStudy.??Processframework—cross-platformandinterdisciplinarybioinformaticsprocessmodelDatamanagementissuesinscientificstudiescanberesolvedwithgoodprocess,whichisextractedandconcludedthroughactualfieldpractice.Aspecificprocessconsistsofasetofwell-organizedmethodsandplatformsfollowingcertainprocedures.ThedesignofaprocesswithflexibilityneedstodelegateboththesimilaritiesandindividualdifferencesofTCMPatternstudy.Itisnecessarytodeterminethegoalofaspecificstudyinordertotailorauniqueprocesswell-fitforit.Keywords:deficiencycoldpattern,bioinformatics,process,epidemiology,pattern,q-PCR,ge