C 反应蛋白、白介素-6、血管表皮生产因子和一氧化氮在胃癌分期及伴随感染中的应用.docVIP

C 反应蛋白、白介素-6、血管表皮生产因子和一氧化氮在胃癌分期及伴随感染中的应用 【摘要】目的测定胃癌患者血清/血浆中的C反应蛋白、白介素-6、血管表皮生长因子和一氧化氮的含量，探讨其在胃癌分期和伴随感染中的应用。方法我们分别测定了70名手术前胃癌患者组和23名健康对照组的血清血管表皮生长因子(vascular endothelial growth factor,VEGF)、白介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)以及血浆一氧化氮(nitric oxide,NO)含量，其中有29名胃癌患者有无确定起因的感染症状。结果伴有和不伴有感染的胃癌组VEGF含量分别为（272.8±112.7）pg/ml和（248.2±101.7）pg/ml，这两组相比无显著性差异（P0.05），与对照组相比，胃癌组VEGF、CRP、IL-6、NO显著升高（P0.01），与非感染组相比，感染组患者CRP、IL-6、NO显著升高（P0.05）。结论尽管胃癌患者血清VEGF水平升高，这可能与感染无关。CRP、IL-6和NO有助于最初评价肿瘤患者的感染状态，IL-6、NO和VEGF作为肿瘤分期是较为有用的参数。 【关键词】 胃癌血管表皮生长因子C 反应蛋白一氧化氮白介素-6 CRP ,IL-6 ,VEGF and NO in diagnosis of infection and staging in patiCRP,IL-6,VEGF and NO in Diagnosis of Infection and Staging in Patients with Gastric Cancer Gu Jin,et al. (Department of Laboratory Science,LianYunGang Municipal Hospital of TCM,LianYunGang,JiangSu 222004 China 【Abstract】 Objective To determine the serum/plasma levels of VEGF,IL-6,NO and CRP in gastric carcinoma and correlations with the stage of the disease and accompanying infection.Methods we examined the levels of serum VEGF,IL-6,CRP and plasma NO in 70 preoperative gastric cancer patients and 23 healthy subjects.There were infection anameses that had no definite origin in 29 cancer patients.Results The VEGF levels (mean±SD;pg/ml) were 272.8±112.7pg/ml and 248.2±101.7pg/ml in gastric cancer patients with and without infection respectively and these values were not significantly different.(P0.05) The levels of VEGF,CRP,IL-6 and NO in cancer patients were significantly higher than those in healthy controls.(P0.01) The levels of CRP,IL-6 and NO were statistically increased in infection group when compared with non-infection group.(P0.05) Conclusions Although Serum VEGF concentrations increase in gastric cancer,this increase might not be related to infection.CRP,IL-6 and NO may help to identify infections in primary evaluation of cancer patients.According to the results of this study,NO,IL-6 and especially VEGF can be used as useful parameters