急性冠状动脉综合征患者血清白细胞介素 37il 37水平及其临床意义-serum interleukin - 37il - 37 level in patients with acute coronary syndrome and its clinical significance.docx

独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文 中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出 贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名： 日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关 部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本 学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存 和汇编本学位论文。保密□ ，在年解密后适用本授权书。 本论文属于不保密□。（请在以上方框内打“√” ）学位论文作者签名：指导教师签名：日期：年月日日期：年月日ContentsABSTRACT …………………………………………………………………………………………………….. 1INTRODUCTION………………………………………………………………………………………………..3METERIALS AND METHODS……………………………………………………………………………21RESULTS………………………………………………………………………………………………………….23DISCUSSION……………………………………………………………………………………………………29CONCLUSION………………………………………………………………………………………………….37REFRENCES…………………………………………………………………………………………………….38ACKNOWLEDGMENTS…………………………………………………………………………………….45Serum level of Interleukin-37 in patients with Acute Coronary Syndrome and its clinical significance.Department of Cardiovascular Medicine, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCandidate: Kisan Kumar Kushwaha Supervisor: Professor Li Dazhu. MD,Ph.DABSTRACT:Objective. Inflammation plays a major role at all stages of the atherosclerosis process from the early events whereby leukocytes are recruited at sites of subendothelial LDL cholesterol accumulation to the late events, when plaque rupture occurs, leading to thrombus formation and adverse acute coronary events. Interleukin-37 (IL-37) is a new anti-inflammatory cytokine of the interleukin-1 family and shown a fundamental inhibitor of innate immunity. However, the role of Interleukin-37 (IL-37) in the modulation of the atherosclerosis process remains unknown. Therefore, we investigated the serum level of interleukin (IL)-37 in patients with acute coronary syndrome.Materials and Methods:A total of 125 patients were enrolled in the study. 30 patients with Myocardial Infarction (MI) and 30 patients with Unstable Angina (UA) as Acute Coronary Syndrome (ACS), 30 patient