急性髓系白血病中flt3 tkd基因突变与预后的meta分析-meta - analysis of flt 3 tkd gene mutation and prognosis in acute myeloid leukemia.docx

独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。本论文属于保密□，在年解密后适用本授权书。不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日期：年月日目录英文缩略词表·····································································1中文摘要···········································································2Abstract4正文部分···········································································6引言···········································································6材料与方法··································································9结果···········································································12讨论···········································································26结论…………………………………………………………….....29参考文献···········································································30致谢················································································35单词缩略表AMLCROSDFSAPLacutemyeloidleukemiacompleteremissionoverallsurvivaldisease-freesurvivalAcutepromyelocyticleukemia急性髓系白血病完全缓解总生存时间无病生存时间急性早幼粒细胞白血病WBCFLT3FLITDTKDwhitebloodcellliketyrosinekinase-3FLT3ligandinternaltandemduplicationstyrosinekinasedomain白细胞fms样酪氨酸激酶3FLT3配体内部串联重复激酶结构域WTROSHRwilttypeReactiveOxygenSpeciesHazardratio野生型活性氧风险比CIConfidenceinterval可信区间SEstandarderror标准误STAT5singaltransducersand信号转导和转录激活因子5activatoroftranscription5华中科技大学同济医学院附属协和医院血液科硕士研究生：刘丹导师：郭涛教授中文摘要目的：评价在急性髓系白血病中，FLT3基因内部串联重复（FLT3-ITD）和第二酪氨酸激酶结构域（FLT3-TKD）点突变的发生情况及与预后的关系。以指导临床选择治疗方案及判断预后。研究设计：Meta分析文献来源：截止到2011年12月1日间在PubMed、EMBase、Cochrane图书馆及中国生物医学数据库中公开发表的关于FLT3基因突变的发生与临床结果的文献。评价指标：完全缓解率（CR）、总体生存时间（OS）、无病生存时间（DFS）。数据提取及统计分析：数据提取及文献偏倚风险评估是有两位研究者独立完成。数据分析采用Stata11.0进行统计分析。方法：检索PubMed、EMBase、Cochrane图书馆及中国生物医学数据库中关于FLT3基因突变的发生与临床结果的文献。检索截止时间为2011年12月1日。采用Stata11.0进行Meta分析。若某些文献所给