急性饮酒早期脑部灌注改变的动脉自旋标记研究-study on arterial spin labeling of brain perfusion changes in early stage of acute drinking.docx

ABSTRACTObjective ：By three-dimensional arterial spin labeling technology (3 d - ASL) on acute alcohol after early brain perfusion (CBF) quantitative change, preliminary analysis of the influence of perfusion of acute alcohol, recognizing drunk perfusion change contact between brain function.Materials and methods：80 healthy volunteers were divided into trial group andthe placebo, 40 people in each group (20) men and women, average age 25.2 ± 2.7 years old.All the volunteers had no personal and family history of alcoholism, mental history of drugs and drug use.Both groups except regular scans brain lesions, the experimental group on an empty stomach some liquor concentration (50%), 1 ml/kg each time, the control group on an empty stomach amount of placebo (amount of pure water), 3.0 THdxT mri scanning equipment by GE.Two groups before the test are scanned for ASL as a baseline, 20 minutes after drinking then test group accepted ASL scanning, were performed before each check blood alcohol concentration and physiological indexes of monitoring.The data was analyzed by SPSS 20.0 statisticalsoftware, group in comparison with paired t test, comparison between the two groups using independent sample t test.The control group and experimental group perfusion values no statistical difference before drinking, left, right brain perfusion values within two way had no statistical difference. The control experiment before and after brain perfusion changes without statistical significance. 21 people among the experimental group 40 (12 male and 9 female) in the cerebral cortex, the thalamus and lentiform nucleus, the cerebellum, medulla oblongata of perfusion increased (P0.05), brain regions compared to left and right are all no statistical significance (P0.05), of which 12 mens frontal cortex perfusion changes the most significant, while women are characterized by increased total cerebral perfusion diffuse. This 21 volunteers becomes more excited for the mood, language, easy to laug