计算机辅助构建pcl-csha仿生髁突复合支架的研究-study on computer-aided construction of pcl - csha bionic condyle composite scaffold.docx

PAGE PAGE IV 摘要 突复合支架具有良好孔隙率和理化性能，孔隙大小从基底层 50μm 往上逐渐递 增，最上层部分孔隙大小在 200-300μm。这种无边界设计方式使软骨及下骨两层 移行区域的材料和孔隙率相互渗透，呈梯度变化,避免了因材料受外力或特殊情 况下出现的裂隙和分离，使骨、软骨两层支架间结合紧密。PCL-CS –HA 复合支 架材料急性全身毒性试验、热原试验、溶血试验均为阴性，肌内植入实验结果 显示 PCL-CS –HA 复合材料支架对细胞有较强的亲和作用。支架具备良好的生 物相容性性，符合组织工程骨支架要求。应用 PCL-CS-HA/TGF-β1 复合支架植 入骨、软骨缺损的兔髁突中能促进软骨缺损的修复。效果优于空白对照组。但 研究仅仅局限于粗浅的观察，研究中还存在较多的问题和思考需要在后续研究 中进一步探讨。 关键词：3D 打印；软骨组织工程；髁突；复合支架，转化生长因子-β1； 原位再生； Ab Abstract PAGE PAGE V ABSTRACT Background and significance TMJ lesions will result in oral and maxillofacial chewing disorders, occlusal disorders, facial deformities and OSAHS and other pathological changes. Epidemiol -ogical investigation shows that the incidence of TMD reaches even as high as 20-25%, the serious TMD can cause joint lesions, such as the damage of condylar bone and cartilage. In addition, the condylar tumors, trauma often lead to condylar defects and damage, even such destructive consequences as condylar resection. For joint lesions of TMJ, clinical therapy needs operation. And the use of autologous bone tissue transplantation for the clinical application of condylar reconstruction and rebuilding is universal. But aotologous bones lack favorable appearance and such application may cause injury of donor site. At present, it is difficult to get satisfactory solution from artificial materials because they fail to meet mechanical toughness requirements. And other problems such as degradation period and postoperative infection also hinder the use of artificial materials. With the continuous development and application of new technologies, such as artificial joints, osteochondral tissue engineering, there are more and more choices for temporomandibular joint reconstruction, condylar defect and missing. But because of the complicated functions and activities involved and unique anatomical morphology of the temporomandibular joint, up till now, there is no prefect method to obtain satisfactory clinical effect to reconstruct or repair temporoman