唐景玲纳米技术改善难溶性药物口服吸收讲解课件.pptVIP

The Stages of Drug Discovery and Development Oral drug absorption Dosage Form Development Strategies A few common strategies to overcome impacts of low solubility on product development: – Salt formation or prodrug – Cyclodextrin inclusion – Solid dispersion – Particle size reduction – Lipid-based drug delivery Particle size reduction Particle size reduction—Patent Nanocrystal technology —Elan corporation The new formulation overcame the drug’s relative insolubility by reducing the particle size to less than 200nm, and subsequently coating the active compound with GRAS (Genera