h,2s缺乏对大鼠肝硬化门静脉压力的影响及其相关酶学研究-effects of h, 2s deficiency on portal vein pressure in rats with cirrhosis and related enzymological studies.docxVIP

Results:The formation of the hepatic cirrhosis animal model of portal hypertension: The hepatic cirrhosis rat model was determined by pathological.It shows the formation of portal hypertension that the portal venous pressure is higher than 1.57Kpa.Measurement of the portal venous pressure: Portal venous pressure in hepatic cirrhosis group increased in comparison with normal group (P0.05); Portal venous pressure in hepatic cirrhosis +PPG group increased in comparison with hepatic cirrhosis group (P0.05); Portal venous pressure in hepatic cirrhosis +ZnPP+L-NAME group decreased in comparison with hepatic cirrhosisgroup(P0.05); Portal venous pressure in hepatic cirrhosis+ZnPP+L-NAME +PPG group decreased in comparison with hepatic cirrhosis+PPG group, and it increased in comparison with in both of hepatic cirrhosis+ZnPP+L-NAME group and hepatic cirrhosis group (P0.05).There was no statistic difference in normal group andnormal+PPG group and normal+ZnPP+L-NAME +PPG group and normal+ZnPP+L-NAME group (P＞0.05).Measurement of the plasma concentration of H2S and NO and CO ①The plasma content of H2S in hepatic cirrhosis group decreased in comparison with normal group (P0.05) ; H2S content a in hepatic cirrhosis +PPG group decreased in comparison with hepatic cirrhosis group (P0.05); H2S content in hepatic cirrhosis +ZnPP+L-NAME group increased in comparison with hepatic cirrhosis group (P0.05); H2S content in hepatic cirrhosis+ZnPP+L-NAME +PPG group decreased in comparison with hepatic cirrhosis group (P0.05). H2S content in normal +PPG group decreased in comparison with normal group (P0.05); H2S content in normal +ZnPP+L-NAME group increased in comparison with normal group (P0.05); H2S content in normal +ZnPP+L-NAME +PPG group decreased in comparison with normal group (P0.05). ②The plasma content of NO and CO in hepatic cirrhosis +PPG group increased in comparison with hepatic cirrhosis group (P0.05); Content of NO and CO in hepatic cirrhosis+ZnPP+L-NAME group