h型高血压和早发冠心病的相关性分析-correlation analysis of h - type hypertension and early coronary heart disease.docx

Ab Abstract PAGE PAGE IV ABSTRACT Objective：To explore the relationship between H-type hypertension and PCAD, and provide PCAD with clinical idea of early diagnose and treatment。 Methods: 197 patients(male55 years old，fermale65 years old) with essential hypertension hospitalised in first affiliated hospital of Nanchang university were collected from 2012.12～2015.4。According to Framinham study,we define coronary artery disease with age(male55 years old ， fermale65 years old) as premature coronary artery disease(PCAD)。All patients were detected homocysteine (Hcy),blood lipids and some other biochemical indicators levels 。 Personal details were collected,for example, history of smoking ， and so on 。 Coronary lesion degree is calculated by gensini score。We separeted PCAD group(n=125) from all patients,the rest of patients are control group(n=72) according to coronary angiography。All the PCAD patients were divided into Acute coronary syndrome (ACS) group(n=35) ， stable angina grou(n=90) 。 Basis on coronary lesion all the PCAD patients were divided into single-vessel lesion group(n=64) and multi-vessel lesions group(n=61) 。 Comparing H-type hypertension prevalence among different groups。With PCAD as dependent variables,H-type hypertension,drinking history and some other biochemical indicators as independent variables,the binary logitic regress analyzes their association 。 We analyze their association between H-type hypertension and PCAD。 Results： 1.H-tye hypertension morbidity,smoking and drinking history are obviously lower in the control group patients than that in the PCAD group(respectively 29.2% vs 76.0% P＜0.001,23.6% vs 52.0% P＜0.001,9.7% vs 21.6% P=0.034)。The male ratio,age,SBP,DBP,uric acid,LDL,HDL,TC and TG in the control group are not statistically different from that of the PCAD group(P＞0.05)。The logistic regression analysis revealed H-type hypertension(OR=3.2) and smoking history(OR=3.0) are risk factors in PCAD。 2.H-type hypertension morbidity,smoking and