颅内节细胞胶质瘤患者病理与鉴别诊断.docVIP

颅内节细胞胶质瘤患者病理与鉴别诊断 　　【中图分类号】R739.4【文献标识码】A【文章编号】1672-3873（2012）03－0247－01 　　【摘要】目的：对节细胞胶质瘤的免疫表型、组织学特征、临床诊治等进行分析与讨论。方法：以我院2001~2011年收治的30例节细胞胶质瘤患者的存档标本作为研究对象，所涉及的标本全部取材，均经10%福尔马林固定，石蜡包埋，5μm厚切边，使用sp两步法和常规HE染色。进行病理学观察和免疫表型总结。结果：肿瘤标本的切面呈灰白色，界限较为清晰，与正常脑组织相比质地略硬，一部分标本表现出了明显的沙砾感。节细胞胶质瘤以星形细胞为胶质的主要成分，但是较少出现核分裂象，未见微血管坏死或增生。节细胞成分表达NF、Syn、MAP2abc、NeuN、CgA，肿瘤性胶质细胞表达Olig-2、S-100、GFAP。结论：节细胞胶质瘤的最佳治疗方式为进行完全切除手术，若因其它因素无法完全切除，必须进行放疗，以免残留肿瘤继续发展。 　　【关键词】节细胞胶质瘤；病例；鉴别；诊断 　　【Abstract】objective: to quarter of gliomas immune cell phenotype, histologic features, clinical diagnosis and treatment are analyzed and discussed. Methods: from 2001 to 2011 of the 30 cases were ganglion cells of the specimen cancerous gliomas file as the research object, involves the specimen all materials, both by 10% formalin fixed, paraffin, 5 μ m thick trimming, useSP two-step and conventional HE dyed. For pathology observation and immune phenotype summary. Results: the cut surface of the tumor samples are pale, a clear boundaries, compared with normal brain tissue slightly hard quality of a material, the part of the specimen showed a clear sense of gravel. The ganglion cells in a star for glial cells glioma, the main component, but less emerged as nuclear division, did not see the microvascular necrosis or hyperplasia. Section cell components express NF, Syn, MAP2abc, NeuN, CgA, cancerous glial cells expressed Olig-2, the S-100, the GFAP. Conclusion: the ganglion cells the best treatment for a way to complete excision surgery, if because of other factors cant complete excision, must radiation therapy, lest residual tumor continue to development. 　　【Keywords】ganglion cells glioma; Cases; Identify; diagnosis 　　节细胞胶质瘤（gangliogliomas，简称GG）是神经系统肿瘤中比较少见的一类???多发于年轻的难治性癫痫患者群体中。肿瘤由胶质瘤细胞和肿瘤性节细胞构成，生长缓慢，分化较好，界限清晰，经手术切除后有较大几率可以治愈。由于节细胞胶质瘤具有独特的病理特征和良好的预后，所以在临床诊疗中必须要将其与其它肿瘤区分开来。本次研究以我院2001~2011年收治的30例节细胞胶质瘤患者的存档标本作为研究对象，对肿瘤的免疫表型、组织学特征、临床诊治等进行分析与讨论，现报告如下。 　　1资料与方法 　　1.1一般资料 　　 本次研究以我院2001~2011年收治的30例节细胞胶质瘤患者的存档标本作为研究对象